GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

Guidelines

MIRAGE

mitochondrial translation release factor in rescue

Summary

Gene Symbol

MTRFR

Organism

Homo sapiens (human)

External Links

NCBI Gene

91574

PubChem

91574

Alliance of Genome Resources

HGNC:26784

JoGo

MTRFR

TogoVar

MTRFR

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Disease variant
Hereditary spastic paraplegia
Methylation
Mitochondrion
Primary mitochondrial disease
Protein biosynthesis
Proteomics identification
RNA-binding
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H3J6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
translational termination	IEA
rescue of stalled ribosome	IDA	33243891

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle disassembly [inference]

ribosome disassembly [inference]

rescue of stalled ribosome

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

translational termination

organelle disassembly [inference]

ribosome disassembly [inference]

rescue of stalled ribosome

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

translational termination

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrion	NAS	20186120
mitochondrion	IDA	20186120 20598281
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial matrix	TAS	33878294

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
tRNA binding	IDA	33243891
translation release factor activity
protein binding	IPI	28514442 31396629 33243891 33961781
translation release factor activity, codon specific	IDA	33878294
ribosomal large subunit binding	IDA	33243891

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding [inference]

ribosomal large subunit binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

tRNA binding

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation termination factor activity [inference]

translation release factor activity

translation release factor activity, codon specific

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation termination factor activity [inference]

translation release factor activity

translation release factor activity, codon specific

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptide chain release factor

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Peptide chain release factor class I superfamily
Peptide chain release factor class I

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110807	hereditary spastic paraplegia 55	Alliance of Genome Resources
DOID:0111487	combined oxidative phosphorylation deficiency 7	Alliance of Genome Resources

About Release Notes Help Feedback

Click here to visit the beta site.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

GlyCosmos Portal v4.4.0

Last updated: December 8, 2025