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interleukin 1 receptor like 1

Summary

Gene Symbol

IL1RL1

Aliases

DER4
FIT-1
IL33R
ST2
ST2L
ST2V
T1
homolog of mouse growth stimulation-expressed

Organism

Homo sapiens (human)

External Links

NCBI Gene

9173

HGNC

5998

PubChem

9173

Alliance of Genome Resources

HGNC:5998

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Immunoglobulin domain
Isopeptide bond
NAD
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q01638	Protein ST2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **11 - 11** of 11 in total

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GO Term	Evidence Code	PMID
positive regulation of inflammatory response	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interleukin-33-mediated signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

regulation of immune response [inference]

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of T-helper 1 type immune response [inference]

negative regulation of T-helper 1 type immune response

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of interleukin-5 production [inference]

positive regulation of interleukin-5 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of interleukin-5 production [inference]

positive regulation of interleukin-5 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of interleukin-5 production [inference]

positive regulation of interleukin-5 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of immune response [inference]

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of T-helper 1 type immune response [inference]

negative regulation of T-helper 1 type immune response

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T-helper 1 type immune response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interleukin-33-mediated signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of interleukin-5 production [inference]

positive regulation of interleukin-5 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

positive regulation of cytokine production [inference]

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

negative regulation of type II interferon production

regulation of interleukin-5 production [inference]

positive regulation of interleukin-5 production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type II interferon production

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GO Term	Evidence Code	PMID
external side of plasma membrane	IEA
focal adhesion	IDA
plasma membrane	IBA IC IDA TAS	16286016
extracellular region	IEA
cell surface	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	16286016 25416956 32296183 8621446
NAD+ nucleosidase activity	IEA
cytokine receptor activity	TAS	10191101
NAD+ nucleotidase, cyclic ADP-ribose generating	IEA
interleukin-1 receptor activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

NAD+ nucleosidase activity

NAD+ nucleotidase, cyclic ADP-ribose generating

binding [inference]

protein binding

cytokine binding [inference]

interleukin-33 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Interleukin-1 receptor type 1

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cytokine-mediated signaling pathway
hydrolase activity
interleukin-1 binding
interleukin-1 receptor activity
interleukin-1-mediated signaling pathway
regulation of inflammatory response

Displaying **all 8** entries
InterPro
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Interleukin-1 receptor family
Interleukin-1 receptor type I/II
Toll/interleukin-1 receptor homology (TIR) domain superfamily
Toll/interleukin-1 receptor homology (TIR) domain

Rhea

H₂O + NAD⁺

H⁺ + nicotinamide + ADP-D-ribose

Enzyme

PMID

Ortholog

Displaying entries **11 - 20** of 59 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Oryctolagus cuniculus	100350150			RABIT08289
Callithrix jacchus	100394304			CALJA11237
Ailuropoda melanoleuca	100476444			AILME18555
Meleagris gallopavo	100542982			MELGA01529
Loxodonta africana	100667977			LOXAF10851
Cavia porcellus	100725581			CAVPO11233
Cavia porcellus	100725851			CAVPO11233
Cricetulus griseus	100760768			CRIGR06580
Sarcophilus harrisii	100914043			SARHA12953
Otolemur garnettii	100958513			OTOGA08223

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Last updated: December 9, 2024