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MTSS I-BAR domain containing 2

Summary

Gene Symbol

MTSS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

92154

PubChem

92154

Alliance of Genome Resources

HGNC:25094

Annotation

Keyword

Actin-binding
Alternative splicing
Cell projection
Coiled coil
Cytoplasm
Disease variant
Intellectual disability
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q765P7	Actin-bundling with BAIAP2 homology protein 1 MTSS1-like protein

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
membrane organization	IBA
activation of GTPase activity	IDA	20875796
cellular response to platelet-derived growth factor stimulus	IDA	20875796
cell projection assembly	IBA
lamellipodium organization	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly

cell projection organization [inference]

cell projection assembly

plasma membrane bounded cell projection organization [inference]

lamellipodium organization

membrane organization

plasma membrane organization

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

response to platelet-derived growth factor [inference]

cellular response to platelet-derived growth factor stimulus

cellular response to growth factor stimulus [inference]

cellular response to platelet-derived growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to platelet-derived growth factor stimulus

biological regulation [inference]

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity [inference]

activation of GTPase activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cortical actin cytoskeleton	IEA
ruffle membrane	IDA	20875796
cytoplasmic side of plasma membrane	IBA
actin cytoskeleton	IBA
lamellipodium	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
GTPase activator activity	IDA	20875796
protein binding	IPI	32296183
actin binding	IBA
small GTPase binding	IPI	20875796
phosphatidylinositol-4,5-bisphosphate binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actin monomer binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

lipid binding [inference]

phospholipid binding

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protein MTSS 1

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
actin binding
cell projection assembly
phospholipid binding
plasma membrane organization

Displaying **all 3** entries
InterPro
AH/BAR domain superfamily
I-BAR domain containing protein MTSS1/MTSS2
IMD/I-BAR domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081301	intellectual developmental disorder with ocular anomalies and distinctive facial features	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172093		WB:WBGene00019771
Mus musculus	244654		MGI:3039591	MOUSE58190
Rattus norvegicus	307845		RGD:1309731	RATNO15213
Pan troglodytes	454219	9598_0:003fa6		PANTR12770
Danio rerio	560413		ZFIN:ZDB-GENE-030219-89
Danio rerio	564555		ZFIN:ZDB-GENE-140718-4	DANRE41709
Canis lupus familiaris	610542			CANLF15969
Macaca mulatta	711946			MACMU27143
Drosophila melanogaster	2768716		FB:FBgn0053558
Monodelphis domestica	100011518			MONDO07914

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OrthoDB (Group)

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Acknowledgements