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VAMP associated protein B and C

Summary

Gene Symbol

VAPB

Organism

Homo sapiens (human)

External Links

NCBI Gene

9217

PubChem

9217

Alliance of Genome Resources

HGNC:12649

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Amyotrophic lateral sclerosis
Coiled coil
Direct protein sequencing
Disease variant
Endoplasmic reticulum
Host-virus interaction
Isopeptide bond
Phosphoprotein
Reference proteome
Transmembrane helix
Ubl conjugation
Unfolded protein response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O95292
Q53XM7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	18713837
endoplasmic reticulum membrane organization	IBA
negative regulation by virus of viral protein levels in host cell	IDA	19515777
endoplasmic reticulum organization	IMP	18713837
modulation by host of viral RNA genome replication	IDA	19515777

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

membrane docking [inference]

organelle localization by membrane tethering [inference]

endoplasmic reticulum-plasma membrane tethering

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization

vesicle organization [inference]

vesicle budding from membrane [inference]

COPII-coated vesicle budding

membrane organization [inference]

vesicle budding from membrane [inference]

COPII-coated vesicle budding

endoplasmic reticulum membrane organization

viral process [inference]

viral release from host cell

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

exit from host cell [inference]

viral release from host cell

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

negative regulation by host of viral process [inference]

negative regulation by host of viral genome replication

positive regulation by host of viral process [inference]

positive regulation by host of viral genome replication

modulation by host of viral genome replication [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

suppression of viral release by host

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus [inference]

suppression of viral release by host

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus [inference]

suppression of viral release by host

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

suppression of viral release by host

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus [inference]

suppression of viral release by host

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

suppression of viral release by host

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus [inference]

suppression of viral release by host

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport

establishment of localization in cell [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

organelle localization [inference]

endoplasmic reticulum localization [inference]

endoplasmic reticulum-plasma membrane tethering

organelle localization by membrane tethering [inference]

endoplasmic reticulum-plasma membrane tethering

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of viral process [inference]

positive regulation of viral genome replication

negative regulation of biological process [inference]

negative regulation of viral process [inference]

negative regulation by virus of viral protein levels in host cell

regulation of viral process [inference]

regulation by virus of viral protein levels in host cell [inference]

negative regulation by virus of viral protein levels in host cell

positive regulation of viral process [inference]

positive regulation of viral genome replication

negative regulation of viral process [inference]

negative regulation by virus of viral protein levels in host cell

regulation of viral life cycle [inference]

regulation of viral genome replication [inference]

positive regulation of viral genome replication

regulation of cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

regulation of biological quality [inference]

regulation by virus of viral protein levels in host cell [inference]

negative regulation by virus of viral protein levels in host cell

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IDA	16227268
postsynapse	IEA
presynapse	IEA
endoplasmic reticulum membrane	IBA IDA TAS	16227268 32344433 33124732
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16227268 18160438 18555774 19289470 19515777 19615732 21976701 22131369 23736259 25616068 25910212 26496610 26618866 28377464 28514442 29858488 30659099 30741634 31515488 32296183 32344433 32814053 33124732 33961781 35156780 35271311 36012204 9920726
FFAT motif binding	IDA IMP IPI	18713837 24105263 33124732
enzyme binding	IPI	17540579
protein heterodimerization activity	IPI	16227268 9920726
microtubule binding	IDA	18713837

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

enzyme binding

protein domain specific binding [inference]

FFAT motif binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

cell adhesion molecule binding [inference]

cadherin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-membrane adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vesicle-associated membrane -associated A

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
FFAT motif binding
endoplasmic reticulum membrane organization
endoplasmic reticulum-plasma membrane tethering

Displaying **all 4** entries
InterPro
Immunoglobulin-like fold
Major sperm protein (MSP) domain
PapD-like superfamily
Vesicle-associated membrane-protein-associated protein

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050752	amyotrophic lateral sclerosis type 8	Alliance of Genome Resources
DOID:0111194	autosomal dominant adult-onset proximal spinal muscular atrophy	Alliance of Genome Resources
DOID:12377	spinal muscular atrophy	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:231	motor neuron disease	Alliance of Genome Resources
DOID:332	amyotrophic lateral sclerosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	31349		FB:FBgn0029687
Mus musculus	56491		MGI:1928744	MOUSE35387
Rattus norvegicus	60431		RGD:68326	RATNO27942
Caenorhabditis elegans	172259		WB:WBGene00018008
Caenorhabditis elegans	185673		WB:WBGene00018354
Caenorhabditis elegans	191101		WB:WBGene00022546
Danio rerio	323628		ZFIN:ZDB-GENE-030131-2348	DANRE39087
Bos taurus	326580			BOVIN04943
Xenopus tropicalis	394500		Xenbase:XB-GENE-6258854
Pan troglodytes	469984	9598_0:0051f5		PANTR25235