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VAMP associated protein A

Summary

Gene Symbol

VAPA

Organism

Homo sapiens (human)

External Links

NCBI Gene

9218

PubChem

9218

Alliance of Genome Resources

HGNC:12648

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Coiled coil
Disulfide bond
Endoplasmic reticulum
Host-virus interaction
Nucleus
Phosphoprotein
Reference proteome
Tight junction
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9P0L0	33 kDa VAMP-associated protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
sphingomyelin biosynthetic process	IMP	12023275
phospholipid transport	IDA	24209621
endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	18713837
endoplasmic reticulum organization	IMP	18713837
cholesterol transport	IDA	33124732

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

amide metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular process [inference]

protein folding [inference]

protein folding in endoplasmic reticulum

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

membrane docking [inference]

organelle localization by membrane tethering [inference]

endoplasmic reticulum-plasma membrane tethering

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization

vesicle organization [inference]

vesicle budding from membrane [inference]

COPII-coated vesicle budding

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

membrane organization [inference]

vesicle budding from membrane [inference]

COPII-coated vesicle budding

membrane fusion

viral process [inference]

viral release from host cell

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

exit from host cell [inference]

viral release from host cell

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

negative regulation by host of viral process [inference]

negative regulation by host of viral genome replication

positive regulation by host of viral process [inference]

positive regulation by host of viral genome replication

modulation by host of viral genome replication [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport

sterol transport

cholesterol transport

ceramide transport

organophosphate ester transport [inference]

phospholipid transport

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport

nitrogen compound transport [inference]

amide transport [inference]

ceramide transport

establishment of localization in cell [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

organelle localization [inference]

endoplasmic reticulum localization [inference]

endoplasmic reticulum-plasma membrane tethering

organelle localization by membrane tethering [inference]

endoplasmic reticulum-plasma membrane tethering

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nuclear membrane	IEA
endoplasmic reticulum membrane	IBA IDA TAS	12023275 30741634 32344433 33124732
plasma membrane	IBA IDA TAS	10523508
endoplasmic reticulum exit site	IDA	18713837
vesicle	IDA	10523508

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

azurophil granule membrane

nuclear membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

azurophil granule membrane

secretory granule membrane [inference]

azurophil granule membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

bicellular tight junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10544080 16227268 16895911 16996479 18160438 19289470 19515777 19615732 20029029 21900206 21957124 21976701 22045669 23736259 23840749 23935497 24105263 24209621 25616068 25681634 25910212 26496610 26618866 28298427 28377464 29858488 29997244 30659099 30741634 31980649 32296183 32344433 32814053 33124732 33961781 35156780 35271311 35384245 36012204
FFAT motif binding	IDA IMP	18713837 33124732
protein heterodimerization activity	IPI	16227268 9920726
microtubule binding	IMP	18713837
protein domain specific binding	IPI	20178991

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

protein domain specific binding

FFAT motif binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

cell adhesion molecule binding [inference]

cadherin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-membrane adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vesicle-associated membrane -associated A

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
FFAT motif binding
endoplasmic reticulum membrane organization
endoplasmic reticulum-plasma membrane tethering

Displaying **all 4** entries
InterPro
Immunoglobulin-like fold
Major sperm protein (MSP) domain
PapD-like superfamily
Vesicle-associated membrane-protein-associated protein

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050752	amyotrophic lateral sclerosis type 8	Alliance of Genome Resources
DOID:0111194	autosomal dominant adult-onset proximal spinal muscular atrophy	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:231	motor neuron disease	Alliance of Genome Resources
DOID:332	amyotrophic lateral sclerosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	30960	MGI:1353561	MOUSE20536
Drosophila melanogaster	31349	FB:FBgn0029687
Rattus norvegicus	58857	RGD:61803	RATNO43020
Caenorhabditis elegans	172259	WB:WBGene00018008
Caenorhabditis elegans	185673	WB:WBGene00018354
Caenorhabditis elegans	191101	WB:WBGene00022546
Rattus norvegicus	317161	RGD:1304785
Danio rerio	334608	ZFIN:ZDB-GENE-030131-6540
Xenopus laevis	379097	Xenbase:XB-GENE-6251818
Danio rerio	436819	ZFIN:ZDB-GENE-040718-281	DANRE30105

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements