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Standards Ontologies Notations
glucosaminyl (N-acetyl) transferase 3, mucin type

Summary
Gene Symbol
  • GCNT3
Aliases
  • C2/4GnT
  • C2GnT-M
  • C2GnT2
Organism
Homo sapiens (human)
External Links
NCBI Gene
9245
GGDB ID
HGNC
4205
mRNA
map
  • 15q21.3
Protein
OMIM
KEGG Gene ID
hsa:9245
PubChem
9245
Alliance of Genome Resources
Annotation
Keyword
  • Disulfide bond
  • Glycoprotein
  • Glycosyltransferase
  • Golgi apparatus
  • Proteomics identification
  • Reference proteome
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
O95395
  • C2GnT-mucin type
  • Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 6 in total
GO Term Evidence Code PMID
protein O-linked glycosylation
carbohydrate metabolic process
tissue morphogenesis
kidney morphogenesis
O-glycan processing
GO Hierarchy
Displaying all 5 entries
GO Term Evidence Code PMID
acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
acetylglucosaminyltransferase activity
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
Human Protein Atlas
ENSG00000140297

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas
GlycoGene Database (GGDB)
GGDB ID
gg108
Gene Symbol
  • GCNT3
Reactions
Displaying all 3 entries
Donor Acceptor Product Reference
UDP-GlcNAc
G00035MO
G00037MO
UDP-GlcNAc
G00031MO
G00033MO
UDP-GlcNAc
G29487JS
G08872UM
Displaying all 5 entries
Donor Acceptor Product Reference
UDP-GlcNAc
G00031MO
G00033MO
UDP-GlcNAc
G00887EN
G79351OB
UDP-GlcNAc
G82440PA
G44848DV
UDP-GlcNAc
G29487JS
G08872UM
UDP-GlcNAc
G00035MO
G00037MO
Displaying all 3 entries
Donor Acceptor Product Reference
UDP-GlcNAc
G33476GF
UDP-GlcNAc
G58896AZ
UDP-GlcNAc
G57321FI
Orthologous Gene
Displaying all 2 entries
Species Protein mRNA
Rattus norvegicus NP_775434 NM_173312
Mus musculus NP_082363 NM_028087
KEGG BRITE Database
Orthology
K09662
Name
N-acetylglucosaminyltransferase 3, mucin type [EC:2.4.1.-]
References
Reactions
Displaying all 2 entries
KEGG Reaction Enzyme Acceptor Product
R05915
R05912
Rhea

RHEA:56192

UDP-N-acetyl-α-D-glucosamine
H+ + UDP
Enzyme
PMID

RHEA:54820

a β-D-Gal-(1→4)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-GlcNAc derivative + UDP-N-acetyl-α-D-glucosamine
a β-D-Gal-(1→4)-β-D-GlcNAc-(1→3)-[β-D-GlcNAc-(1→6)]-β-D-Gal-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H+ + UDP
Enzyme
PMID

RHEA:56216

UDP-N-acetyl-α-D-glucosamine
H+ + UDP
Enzyme
PMID

RHEA:17413

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + UDP-N-acetyl-α-D-glucosamine
an N-acetyl-β-D-glucosaminyl-(1→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H+ + UDP
Enzyme
PMID

RHEA:56212

UDP-N-acetyl-α-D-glucosamine
H+ + UDP
Enzyme
PMID

RHEA:56188

UDP-N-acetyl-α-D-glucosamine
H+ + UDP
Enzyme
PMID
Disease
Disease Ontology
Displaying entries 1 - 10 of 18 in total
DO ID Disease Name Source
DOID:0080199 colorectal carcinoma
DOID:1324 lung cancer
DOID:1520 colon carcinoma
DOID:162 cancer
DOID:1793 pancreatic cancer
DOID:1909 melanoma
DOID:219 colon cancer
DOID:235 colonic benign neoplasm
DOID:2394 ovarian cancer
DOID:3571 liver cancer
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP006286
Gene Name
glucosaminyl (N-acetyl) transferase 3, mucin type
Ortholog
Displaying entries 1 - 10 of 102 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
172446 WB:WBGene00001643
172447 WB:WBGene00001644
173108 WB:WBGene00001642
173109 WB:WBGene00001641
173114 WB:WBGene00001640
174679 WB:WBGene00001626
103188734 CALMI04239
100332076 ZFIN:ZDB-GENE-110411-253
103043498 ASTMX05132
105008128 ESOLU55432
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024