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multifunctional ROCO family signaling regulator 1

Summary

Gene Symbol

MFHAS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9258

PubChem

9258

Alliance of Genome Resources

HGNC:16982

Annotation

Keyword

Acetylation
Chromosomal rearrangement
Cytoplasm
GTP-binding
Inflammatory response
Innate immunity
Leucine-rich repeat
Reference proteome
Repeat
Signal transduction inhibitor
Tumor suppressor
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y4C4	Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 17** of 17 in total

« First

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GO Term	Evidence Code	PMID
negative regulation of toll-like receptor 4 signaling pathway	IMP	28609714
positive regulation of p38MAPK cascade	IMP	28471450

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

signal transduction

intracellular signal transduction

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of leukocyte activation [inference]

regulation of macrophage activation

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of toll-like receptor 2 signaling pathway [inference]

regulation of toll-like receptor 4 signaling pathway [inference]

negative regulation of toll-like receptor 4 signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

negative regulation of signal transduction [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of toll-like receptor 2 signaling pathway [inference]

regulation of toll-like receptor 4 signaling pathway [inference]

negative regulation of toll-like receptor 4 signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of JNK cascade [inference]

positive regulation of JNK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of JNK cascade [inference]

positive regulation of JNK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

negative regulation of protein localization to nucleus

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of toll-like receptor 2 signaling pathway [inference]

regulation of toll-like receptor 4 signaling pathway [inference]

negative regulation of toll-like receptor 4 signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

negative regulation of signal transduction [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of toll-like receptor 2 signaling pathway [inference]

regulation of toll-like receptor 4 signaling pathway [inference]

negative regulation of toll-like receptor 4 signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of JNK cascade [inference]

positive regulation of JNK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of JNK cascade [inference]

positive regulation of JNK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of toll-like receptor 2 signaling pathway [inference]

regulation of toll-like receptor 4 signaling pathway [inference]

negative regulation of toll-like receptor 4 signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of inflammatory response [inference]

negative regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of toll-like receptor 2 signaling pathway [inference]

regulation of toll-like receptor 4 signaling pathway [inference]

negative regulation of toll-like receptor 4 signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of toll-like receptor 2 signaling pathway [inference]

regulation of toll-like receptor 4 signaling pathway [inference]

negative regulation of toll-like receptor 4 signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of JNK cascade [inference]

positive regulation of JNK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of cellular process [inference]

signal transduction

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

negative regulation of signal transduction [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of toll-like receptor 2 signaling pathway [inference]

regulation of toll-like receptor 4 signaling pathway [inference]

negative regulation of toll-like receptor 4 signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of JNK cascade [inference]

positive regulation of JNK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of JNK cascade [inference]

positive regulation of JNK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of macrophage activation

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

negative regulation of protein localization to nucleus

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of JNK cascade [inference]

positive regulation of JNK cascade

regulation of p38MAPK cascade [inference]

positive regulation of p38MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of macrophage activation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrion	IDA	24286120
lysosome	IDA	24286120
cytoskeleton	IDA	24286120
cytoplasm	IDA	24286120 28471450

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23327923 24286120 28609714 29513927 33961781
protein phosphatase 2A binding	IDA	28609714
ubiquitin protein ligase binding	IPI	28471450
GTP binding	IDA	24286120

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding [inference]

protein phosphatase 2A binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:4415	fibrous histiocytoma	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 91 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	100125009		Xenbase:XB-GENE-1003080
Taeniopygia guttata	100217808			TAEGU24012
Oryctolagus cuniculus	100353570			RABIT14412
Callithrix jacchus	100402766			CALJA09095
Ailuropoda melanoleuca	100469096			AILME10650
Nomascus leucogenys	100594849			NOMLE29057
Sus scrofa	100623863			PIGXX09233
Loxodonta africana	100671758			LOXAF12260
Oreochromis niloticus	100703018			ORENI64905
Cavia porcellus	100732163			CAVPO23154

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Last updated: December 9, 2024