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glyoxylate and hydroxypyruvate reductase
Summary
- Gene Symbol
-
- GRHPR
- Aliases
-
- PH2
- primary hyperoxaluria type 2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- NADP
- Oxidoreductase
- Phosphoprotein
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A384N605 |
|
| Q9UBQ7 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| carboxylic acid metabolic process |
|
|
| glyoxylate metabolic process | ||
| dicarboxylic acid metabolic process |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytosol | ||
| cytoplasm | ||
| catalytic complex | ||
| peroxisomal matrix |
|
|
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| carboxylic acid binding | ||
| glyoxylate reductase (NADP+) activity | ||
| protein homodimerization activity | ||
| NADPH binding | ||
| hydroxypyruvate reductase activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080301 | atypical hemolytic-uremic syndrome | |
| DOID:0111671 | primary hyperoxaluria type 2 | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma | |
| DOID:10575 | calcium metabolism disease | |
| DOID:1074 | kidney failure | |
| DOID:12554 | hemolytic-uremic syndrome | |
| DOID:12678 | hypercalcemia | |
| DOID:12679 | nephrocalcinosis | |
| DOID:182 | calcinosis |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000010 | Recurrent urinary tract infections |
| HP:0000083 | Renal insufficiency |
| HP:0000121 | Nephrocalcinosis |
| HP:0000787 | Nephrolithiasis |
| HP:0000790 | Hematuria |
| HP:0003159 | Hyperoxaluria |
| HP:0006000 | Ureteral obstruction |
| HP:0008672 | Calcium oxalate nephrolithiasis |
| Disease ID | Disease Name |
|---|---|
| OMIM:260000 |
|
| ORPHA:93599 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 40708 | FB:FBgn0037370 | ||
| 100178763 | CIOIN03389 | ||
| 103182154 | CALMI24436 | ||
| 102347981 | LATCH10855 | ||
| 497183 | ZFIN:ZDB-GENE-040724-230 | DANRE06801 | |
| 402985 | ZFIN:ZDB-GENE-040426-1847 | ||
| 100528185 | ICTPU34775 | ||
| 113582659 | ELEEL30192 | ||
| 115173400 | SALTR45352 | ||
| 115205327 | SALTR113227 |
