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Submissions

3-hexulose-6-phosphate synthase (HPS)

Summary

Gene Symbol

hxlA

Organism

Bacillus subtilis subsp. subtilis str. 168

External Links

NCBI Gene: 938314
PubChem: 938314

Annotation

Keyword

Carbohydrate metabolism
Detoxification
Lyase
One-carbon metabolism
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P42405	D-arabino-3-hexulose-6-phosphate formaldehyde lyase HUMPS
A0A6M3Z7A7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
one-carbon metabolic process
L-ascorbic acid catabolic process
formaldehyde assimilation via ribulose monophosphate cycle
'de novo' pyrimidine nucleobase biosynthetic process
response to toxic substance

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

formaldehyde metabolic process [inference]

formaldehyde assimilation [inference]

formaldehyde assimilation via ribulose monophosphate cycle

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

one-carbon metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

lactone metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

lactone catabolic process [inference]

L-ascorbic acid catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

one-carbon metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

formaldehyde metabolic process [inference]

formaldehyde assimilation [inference]

formaldehyde assimilation via ribulose monophosphate cycle

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

cellular aldehyde metabolic process [inference]

formaldehyde metabolic process [inference]

formaldehyde assimilation [inference]

formaldehyde assimilation via ribulose monophosphate cycle

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

lactone metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

lactone catabolic process [inference]

L-ascorbic acid catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

organic cyclic compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

formaldehyde metabolic process [inference]

formaldehyde assimilation [inference]

formaldehyde assimilation via ribulose monophosphate cycle

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

one-carbon metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

lactone metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

lactone catabolic process [inference]

L-ascorbic acid catabolic process

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

Displaying **all 3** entries
GO Term	Evidence Code	PMID
orotidine-5'-phosphate decarboxylase activity
3-dehydro-L-gulonate-6-phosphate decarboxylase activity
hexulose-6-phosphate synthase activity

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

aldehyde-lyase activity [inference]

hexulose-6-phosphate synthase activity

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:25201

formaldehyde + D-ribulose 5-phosphate

D-arabino-hex-3-ulose 6-phosphate

Enzyme

4.1.2.43

PMID

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements