GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Heparin-binding
Hydrolase
Lipid degradation
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9Y5X9	Endothelial cell-derived lipase Phospholipase A1
B4DTR8	Phospholipase A1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
phospholipid homeostasis	IMP	19136670
lipid metabolic process	TAS	10192396 10318835
lipid catabolic process
phospholipid catabolic process	NAS	19136670
high-density lipoprotein particle remodeling	IBA IMP	19136670

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

phospholipid metabolic process [inference]

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

primary metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process

lipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

phospholipid metabolic process [inference]

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

lipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process

lipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

phospholipid metabolic process [inference]

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

phospholipid metabolic process [inference]

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

phospholipid homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to chemical [inference]

response to nutrient

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

reverse cholesterol transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

reverse cholesterol transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of lipoprotein metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of lipoprotein metabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of lipoprotein metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of lipoprotein metabolic process

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of multicellular organismal process [inference]

positive regulation of lipoprotein particle clearance [inference]

positive regulation of high-density lipoprotein particle clearance

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of lipoprotein metabolic process

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

regulation of high-density lipoprotein particle clearance [inference]

positive regulation of high-density lipoprotein particle clearance

positive regulation of lipoprotein particle clearance [inference]

positive regulation of high-density lipoprotein particle clearance

positive regulation of multicellular organismal process [inference]

positive regulation of lipoprotein particle clearance [inference]

positive regulation of high-density lipoprotein particle clearance

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	IBA IDA	10192396
extracellular region	TAS
Golgi apparatus	IDA	23918928
early endosome	IDA	23918928
cell surface	IDA	23918928

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
triglyceride lipase activity	IDA	12032167
phospholipase activity	IDA	10192396
phospholipase A1 activity	IBA IDA IEA	10318835 12032167
1-acyl-2-lysophosphatidylserine acylhydrolase activity
phosphatidylserine 1-acylhydrolase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity

triglyceride lipase activity

lipoprotein lipase activity

carboxylic ester hydrolase activity [inference]

triglyceride lipase activity

lipoprotein lipase activity

binding [inference]

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lipase I

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
lipase activity
lipid metabolic process

Displaying **all 4** entries
InterPro
Alpha/Beta hydrolase fold
Lipase, N-terminal
Lipase
Triacylglycerol lipase family

KEGG BRITE Database

Orthology

K22284

Name

endothelial lipase [EC:3.1.1.3]

References

10192396

Rhea

RHEA:18689

H₂O + a 1,2-diacyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + a 2-acyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.32

PMID

RHEA:12044

H₂O + a triacylglycerol

H⁺ + a diacylglycerol + a fatty acid

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1287	cardiovascular system disease	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006636
Gene Name: lipase, endothelial

Ortholog

Displaying entries **1 - 10** of **116** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16891	MGI:1341803	MOUSE24376
Drosophila melanogaster	31925	FB:FBgn0030162
Drosophila melanogaster	31938	FB:FBgn0005391
Drosophila melanogaster	31939	FB:FBgn0004045
Drosophila melanogaster	32339	FB:FBgn0004047
Drosophila melanogaster	32708	FB:FBgn0265267
Drosophila melanogaster	32709	FB:FBgn0030828
Drosophila melanogaster	32778	FB:FBgn0030884
Drosophila melanogaster	33429	FB:FBgn0031426
Drosophila melanogaster	33751	FB:FBgn0250847

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements