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fatty acid desaturase 2

Summary

Gene Symbol

FADS2

Aliases

D6D
DES6
FADSD6
SLL0262
TU13
delta-6-desaturase

Organism

Homo sapiens (human)

External Links

NCBI Gene

9415

HGNC

3575

KEGG Gene ID

hsa:9415

PubChem

9415

Alliance of Genome Resources

HGNC:3575

Annotation

Keyword

Alternative splicing
Electron transport
Endoplasmic reticulum
Fatty acid biosynthesis
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O95864	Delta(6) fatty acid desaturase Fatty acid desaturase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
positive regulation of cellular response to oxidative stress	IEA
unsaturated fatty acid biosynthetic process	IEA
lipid metabolic process	IBA
alpha-linolenic acid metabolic process
arachidonic acid metabolite production involved in inflammatory response	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

lipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

olefinic compound metabolic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

multicellular organismal process [inference]

production of molecular mediator involved in inflammatory response [inference]

arachidonic acid metabolite production involved in inflammatory response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular response to oxidative stress

positive regulation of response to stimulus [inference]

positive regulation of response to oxidative stress [inference]

positive regulation of cellular response to oxidative stress

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to oxidative stress [inference]

positive regulation of cellular response to oxidative stress

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress [inference]

positive regulation of cellular response to oxidative stress

regulation of response to oxidative stress [inference]

regulation of cellular response to oxidative stress [inference]

positive regulation of cellular response to oxidative stress

positive regulation of response to oxidative stress [inference]

positive regulation of cellular response to oxidative stress

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular response to oxidative stress

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress [inference]

positive regulation of cellular response to oxidative stress

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane
plasma membrane		9867867
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IBA
linoleoyl-CoA desaturase activity
stearoyl-CoA 9-desaturase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

acyl-CoA desaturase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000134824

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K10226

Name

acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]

References

9867867

Rhea

RHEA:47144

H⁺ + O₂ + (9Z,12Z,15Z)-octadecatrienoyl-CoA

H₂O + (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA

Enzyme

1.14.19.3

PMID

RHEA:47140

H⁺ + O₂ + (9Z,12Z)-octadecadienoyl-CoA

H₂O + (6Z,9Z,12Z)-octadecatrienoyl-CoA

Enzyme

1.14.19.3

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050328	congenital hypothyroidism	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET
DOID:0060041	autism spectrum disorder	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0060224	atrial fibrillation	DisGeNET
DOID:0060357	chylomicron retention disease	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0090004	progressive pseudorheumatoid arthropathy of childhood	DisGeNET
DOID:0110892	inflammatory bowel disease 1	DisGeNET
DOID:0111029	hemochromatosis type 1	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006633
Gene Name: fatty acid desaturase 2

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	177820	WB:WBGene00001395
Danio rerio	140615	ZFIN:ZDB-GENE-011212-1
Xenopus laevis	399058	Xenbase:XB-GENE-17338448
Xenopus laevis	446688	Xenbase:XB-GENE-1010233
Xenopus tropicalis	100145314	Xenbase:XB-GENE-1010230
Callithrix jacchus	100387410		CALJA04466
Cercocebus atys	105577581		CERAT20970
Macaca fascicularis	101926688		MACFA08815
Macaca mulatta	719037		MACMU08963
Macaca nemestrina	105469424		MACNE28693

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements