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eukaryotic translation initiation factor 2 alpha kinase 3

Summary

Gene Symbol

EIF2AK3

Organism

Homo sapiens (human)

External Links

NCBI Gene

9451

PubChem

9451

Alliance of Genome Resources

HGNC:3255

Annotation

Keyword

3D-structure
ADP-ribosylation
ATP-binding
Diabetes mellitus
Disease variant
Endoplasmic reticulum
Glycoprotein
Initiation factor
Kinase
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase
Signal
Stress response
Translation regulation
Transmembrane helix
Unfolded protein response

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q9NZJ5	PRKR-like endoplasmic reticulum kinase Pancreatic eIF2-alpha kinase
Q68DI6
B3KY45
A0A804HIT4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
eiF2alpha phosphorylation in response to endoplasmic reticulum stress	IMP TAS	22934019 25329545
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP	23000344
positive regulation of protein localization to nucleus	ISS
bone mineralization	ISS
response to manganese-induced endoplasmic reticulum stress	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

cellular developmental process [inference]

cell development [inference]

chondrocyte development

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress

ER overload response

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to cold

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to biotic stimulus [inference]

ER overload response

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

endocrine pancreas development

cell development [inference]

chondrocyte development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell development [inference]

chondrocyte development

response to stimulus [inference]

response to stress [inference]

response to cold [inference]

cellular response to cold

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress

ER overload response

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to cold

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

response to starvation [inference]

cellular response to starvation [inference]

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

response to starvation [inference]

cellular response to starvation [inference]

response to amino acid starvation [inference]

cellular response to amino acid starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

response to biotic stimulus [inference]

cellular response to biotic stimulus [inference]

ER overload response

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold [inference]

cellular response to cold

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to manganese ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress

ER overload response

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to cold

integrated stress response signaling [inference]

PERK-mediated unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to biotic stimulus [inference]

ER overload response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of myelination

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin-like growth factor receptor signaling pathway

endoplasmic reticulum unfolded protein response

PERK-mediated unfolded protein response

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of translation in response to stress

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

regulation of myelination [inference]

negative regulation of myelination

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of translation in response to stress

negative regulation of translational initiation

negative regulation of translational initiation in response to stress

negative regulation of myelination

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of myelination

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

negative regulation of myelination

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

activation of cysteine-type endopeptidase activity involved in apoptotic process

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GO Term	Evidence Code	PMID
membrane	HDA	19946888
endoplasmic reticulum membrane	ISS NAS TAS	11907036 22013210 22934019
endoplasmic reticulum	IC ISS TAS	11907036 12086964
nucleus	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

perinuclear region of cytoplasm

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GO Term	Evidence Code	PMID
eukaryotic translation initiation factor 2alpha kinase activity	IBA IDA IMP	10026192 10677345 11907036 12086964 25329545
protein binding	IPI	11907036 25393282 26268696 27238082
protein serine kinase activity	IEA
Hsp90 protein binding	IEA
enzyme binding	IPI	23103912

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

binding [inference]

protein binding

enzyme binding

phosphatase binding [inference]

protein phosphatase binding

heat shock protein binding [inference]

Hsp90 protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
eukaryotic translation initiation factor 2alpha kinase activity
kinase activity
nucleotide binding
phosphorylation

Displaying **all 4** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0090060	Wolcott-Rallison syndrome	Alliance of Genome Resources
DOID:5453	pulmonary venoocclusive disease	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13666		MGI:1341830	MOUSE47763
Rattus norvegicus	29702		RGD:70884	RATNO31925
Drosophila melanogaster	40653		FB:FBgn0037327
Caenorhabditis elegans	181334		WB:WBGene00003970
Caenorhabditis elegans	189655		WB:WBGene00012586
Xenopus laevis	403386		Xenbase:XB-GENE-989852
Pan troglodytes	459388	9598_0:000a5f		PANTR28143
Canis lupus familiaris	475756			CANLF05142
Bos taurus	535820			BOVIN02520
Danio rerio	559564		ZFIN:ZDB-GENE-050414-2	DANRE46701

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements