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D-lactate dehydrogenase

Summary

Gene Symbol

ldhA

Organism

Escherichia coli str. K-12 substr. MG1655

External Links

NCBI Gene: 946315
PubChem: 946315

Annotation

Keyword

3D-structure
NAD
Oxidoreductase
Reference proteome
Stress response

Proteins

Displaying 1 entry
UniProt	Protein Name
P52643	Fermentative lactate dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
response to heat	IEP	15757896 8349564
protein homotetramerization	IDA	25401076
mixed acid fermentation	IDA IMP	2644194 2681156

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

acetate metabolic process [inference]

mixed acid fermentation

formate metabolic process [inference]

mixed acid fermentation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

acetate metabolic process [inference]

mixed acid fermentation

lactate metabolic process [inference]

mixed acid fermentation

formate metabolic process [inference]

mixed acid fermentation

dicarboxylic acid metabolic process [inference]

2-oxoglutarate metabolic process [inference]

mixed acid fermentation

succinate metabolic process [inference]

mixed acid fermentation

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

fermentation [inference]

glycolytic fermentation [inference]

mixed acid fermentation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

mixed acid fermentation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

mixed acid fermentation

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

ethanol metabolic process [inference]

mixed acid fermentation

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

acetate metabolic process [inference]

mixed acid fermentation

lactate metabolic process [inference]

mixed acid fermentation

formate metabolic process [inference]

mixed acid fermentation

dicarboxylic acid metabolic process [inference]

2-oxoglutarate metabolic process [inference]

mixed acid fermentation

succinate metabolic process [inference]

mixed acid fermentation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

mixed acid fermentation

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

acetate metabolic process [inference]

mixed acid fermentation

lactate metabolic process [inference]

mixed acid fermentation

formate metabolic process [inference]

mixed acid fermentation

dicarboxylic acid metabolic process [inference]

2-oxoglutarate metabolic process [inference]

mixed acid fermentation

succinate metabolic process [inference]

mixed acid fermentation

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

ethanol metabolic process [inference]

mixed acid fermentation

lactate metabolic process [inference]

mixed acid fermentation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

acetate metabolic process [inference]

mixed acid fermentation

lactate metabolic process [inference]

mixed acid fermentation

formate metabolic process [inference]

mixed acid fermentation

dicarboxylic acid metabolic process [inference]

2-oxoglutarate metabolic process [inference]

mixed acid fermentation

succinate metabolic process [inference]

mixed acid fermentation

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

fermentation [inference]

glycolytic fermentation [inference]

mixed acid fermentation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

response to stimulus [inference]

response to stress [inference]

response to heat

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IDA	18304323
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
oxidoreductase activity	IEA
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
NAD binding	IEA
NADH binding	IDA	4297265
D-lactate dehydrogenase activity	IBA IDA IEA	2644194

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

lactate dehydrogenase activity [inference]

D-lactate dehydrogenase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

D-lactate dehydrogenase activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADH binding

ion binding [inference]

anion binding [inference]

NADH binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADH binding

Gene Ontology information from NCBI Gene and UniProt.

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024