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BAG cochaperone 3

Summary

Gene Symbol

BAG3

Organism

Homo sapiens (human)

External Links

NCBI Gene

9531

PubChem

9531

Alliance of Genome Resources

HGNC:939

Annotation

Keyword

Acetylation
Apoptosis
Cardiomyopathy
Chaperone
Cytoplasm
Disease variant
Isopeptide bond
Methylation
Myofibrillar myopathy
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O95817	Bcl-2-associated athanogene 3 Bcl-2-binding protein Bis Docking protein CAIR-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
protein folding	NAS	9873016
protein stabilization	IBA IDA	18006506
cellular response to mechanical stimulus	IEA
striated muscle cell apoptotic process	IEA
cellular response to heat	IDA	26159920

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

chaperone-mediated autophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

chaperone-mediated autophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

protein metabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

chaperone-mediated autophagy

cellular process [inference]

protein folding

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

muscle cell apoptotic process [inference]

striated muscle cell apoptotic process

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

chaperone-mediated autophagy

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

protein transport along microtubule

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

process utilizing autophagic mechanism [inference]

autophagy [inference]

chaperone-mediated autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

inclusion body assembly [inference]

aggresome assembly

organelle assembly [inference]

autophagosome assembly

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

response to stimulus [inference]

response to stress [inference]

response to heat [inference]

cellular response to heat

cellular response to stress [inference]

cellular response to heat

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

cellular response to heat

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

protein transport along microtubule

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

microtubule-based transport [inference]

transport along microtubule [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

protein transport along microtubule

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

protein transport along microtubule

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport along microtubule

microtubule-based protein transport [inference]

protein transport along microtubule

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of aggrephagy [inference]

positive regulation of aggrephagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of aggrephagy [inference]

positive regulation of aggrephagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of aggrephagy [inference]

positive regulation of aggrephagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

regulation of protein export from nucleus [inference]

positive regulation of protein export from nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

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GO Term	Evidence Code	PMID
membrane	IBA
aggresome	TAS	21681022
nucleoplasm	IDA
protein folding chaperone complex	IDA	18006506
nucleus	IBA IDA	26159920

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

protein folding chaperone complex

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

aggresome

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
protein binding	IPI	16189514 19229298 21044950 21516116 22366786 23434281 24318877 24510904 25036637 25277244 25416956 26159920 26496610 27880917 28144995 28514442 31515488 32296183 32707033 32814053 33961781
protein carrier chaperone	TAS	21681022
protein-containing complex binding	IEA
dynein intermediate chain binding	NAS	21252941
protein-folding chaperone binding	IBA IPI	18006506

GO Hierarchy

molecular function

binding [inference]

protein binding

dynein intermediate chain binding

cell adhesion molecule binding [inference]

cadherin binding

protein-folding chaperone binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl-nucleotide exchange factor activity

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl-nucleotide exchange factor activity

molecular function regulator activity [inference]

ATPase regulator activity [inference]

adenyl-nucleotide exchange factor activity

molecular carrier activity [inference]

protein carrier chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

BAG domain-containing protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
protein-folding chaperone binding

Displaying **all 2** entries
InterPro
BAG domain superfamily
BAG domain

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0080097	myofibrillar myopathy 6	Alliance of Genome Resources
DOID:0110448	dilated cardiomyopathy 1HH	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	29810		MGI:1352493	MOUSE54182
Drosophila melanogaster	39518		FB:FBgn0086708
Rattus norvegicus	293524		RGD:1307794	RATNO16155
Xenopus laevis	379174		Xenbase:XB-GENE-969280
Danio rerio	445139		ZFIN:ZDB-GENE-040801-40	DANRE05729
Pan troglodytes	450778	9598_0:002b48		PANTR01675
Canis lupus familiaris	486916			CANLF11527
Macaca mulatta	714420			MACMU45212
Bos taurus	782633			BOVIN21653
Monodelphis domestica	100026066			MONDO03074

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements