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Guidelines

MIRAGE

growth differentiation factor 3

Summary

Gene Symbol

GDF3

Organism

Homo sapiens (human)

External Links

NCBI Gene

9573

PubChem

9573

Alliance of Genome Resources

HGNC:4218

Annotation

Keyword

Cleavage on pair of basic residues
Cytokine
Cytoplasm
Developmental protein
Disease variant
Disulfide bond
Glycoprotein
Growth factor
Microphthalmia
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NR23

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
skeletal system development	IMP	19864492
eye development	IMP	19864492
in utero embryonic development	IEA
response to dietary excess	IEA
signal transduction	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

pattern specification process [inference]

axis specification [inference]

embryonic axis specification [inference]

somite rostral/caudal axis specification

anterior/posterior axis specification [inference]

somite rostral/caudal axis specification

embryonic pattern specification [inference]

embryonic axis specification [inference]

somite rostral/caudal axis specification

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

tissue development [inference]

animal organ development [inference]

sensory organ development [inference]

eye development

embryonic organ development [inference]

notochord development

system development [inference]

skeletal system development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis [inference]

response to dietary excess

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to dietary excess

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of developmental process [inference]

regulation of cell fate commitment

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of myoblast differentiation [inference]

negative regulation of myoblast differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of myoblast differentiation [inference]

negative regulation of myoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epidermal cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
cytoplasm	IDA	21805089

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytokine activity	IBA
growth factor activity	IEA
protein kinase binding	IPI	21805089

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Bone morphogenetic protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytokine activity
growth factor activity

Displaying **all 5** entries
InterPro
Cystine-knot cytokine
TGF-beta, propeptide
Transforming growth factor beta, conserved site
Transforming growth factor-beta, C-terminal
Transforming growth factor-beta-related

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060838	isolated microphthalmia 7	Alliance of Genome Resources
DOID:0080591	Klippel-Feil syndrome 3	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 54 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Macaca nemestrina	105484239		MACNE35614
Mandrillus leucophaeus	105541833		MANLE25352
Cercocebus atys	105583072		CERAT30023
Aotus nancymaae	105732606		AOTNA40865
Propithecus coquereli	105805056		PROCO19137
Equus asinus asinus	106837456		EQUAS05604
Rhinopithecus bieti	108542011		RHIBE30690
Phascolarctos cinereus	110213870		PHACI09086
Vulpes vulpes	112917583		VULVU07515
Bos indicus x Bos taurus	113893622		BOBOX41036

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Last updated: December 8, 2025