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cadherin EGF LAG seven-pass G-type receptor 1

Summary

Gene Symbol

CELSR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9620

PubChem

9620

Alliance of Genome Resources

HGNC:1850

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell membrane
Developmental protein
Disease variant
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Hydroxylation
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NYQ6	Cadherin family member 9 Flamingo homolog 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 17 in total

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GO Term	Evidence Code	PMID
establishment of planar polarity	ISS
regulation of actin cytoskeleton organization	ISS
establishment of body hair planar orientation	ISS
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
apical protein localization	ISS

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell motility [inference]

cell migration [inference]

neuron migration

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

establishment of planar polarity of embryonic epithelium

establishment of body hair or bristle planar orientation [inference]

establishment of body hair planar orientation

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

dichotomous subdivision of an epithelial terminal unit [inference]

dichotomous subdivision of terminal units involved in lung branching [inference]

lateral sprouting from an epithelium [inference]

lateral sprouting involved in lung morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

system development [inference]

central nervous system development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	TAS	10716726
plasma membrane	IDA
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane

plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cadherin EGF LAG seven-pass G-type receptor 3

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
calcium ion binding
cell surface receptor signaling pathway

Displaying 1 entry
InterPro
GPCR, family 2-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050580	hereditary lymphedema	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Dipodomys ordii	105992710		DIPOR18829
Salmo salar	106609112		SALSA134171
Equus asinus asinus	106845908		EQUAS22532
Sinocyclocheilus grahami	107569230		SINGR85607
Ictalurus punctatus	108279891		ICTPU12548
Pygocentrus nattereri	108427079		PYGNA09017
Xenopus laevis	108710268	Xenbase:XB-GENE-17338867
Xenopus laevis	108713085	Xenbase:XB-GENE-6486078
Cyprinus carpio carpio	109060941		CYPCA62293
Crocodylus porosus	109315695		CROPO05140

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements