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tubulin tyrosine ligase like 4

Summary

Gene Symbol

TTLL4

Organism

Homo sapiens (human)

External Links

NCBI Gene

9654

PubChem

9654

Alliance of Genome Resources

HGNC:28976

JoGo

TTLL4

TogoVar

TTLL4

Annotation

Keyword

3D-structure
ATP-binding
Cilium
Cytoskeleton
Ligase
Magnesium
Metal-binding
Microtubule
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14679	Protein monoglutamylase TTLL4 Tubulin--tyrosine ligase-like protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IBA
protein polyglutamylation	ISS	21074048
peptidyl-glutamic acid modification	ISS
regulation of blastocyst development	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification

protein polyglutamylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification

protein polyglutamylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification

protein polyglutamylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification

protein polyglutamylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification

protein polyglutamylation

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of blastocyst development

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytosol	TAS
microtubule	IEA
cilium
ciliary basal body	IBA
9+0 non-motile cilium	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

ciliary basal body

cytosol

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

non-motile cilium [inference]

9+0 non-motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

non-motile cilium [inference]

9+0 non-motile cilium

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
tubulin binding	ISS	21074048
tubulin binding	IBA
metal ion binding	IEA
protein-glutamic acid ligase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

acid-amino acid ligase activity [inference]

protein-glutamic acid ligase activity

catalytic activity, acting on a protein [inference]

protein-glutamic acid ligase activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tubulin polyglutamylase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
microtubule cytoskeleton organization
tubulin binding
tubulin-glutamic acid ligase activity

Displaying 1 entry
InterPro
Tubulin-tyrosine ligase/Tubulin polyglutamylase

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements