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TELO2 interacting protein 1

Summary

Gene Symbol

TTI1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9675

PubChem

9675

Alliance of Genome Resources

HGNC:29029

Annotation

Keyword

3D-structure
Cytoplasm
Disease variant
Intellectual disability
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O43156	Protein SMG10

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
regulation of TOR signaling	IMP	23263282
protein stabilization	NAS	20810650
positive regulation of DNA damage checkpoint	NAS	20810650
positive regulation of DNA damage checkpoint	IMP	36724785

GO Hierarchy

biological process

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of cell cycle checkpoint [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of DNA damage checkpoint [inference]

positive regulation of DNA damage checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of cell cycle checkpoint [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of DNA damage checkpoint [inference]

positive regulation of DNA damage checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA damage checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of cell cycle checkpoint [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of DNA damage checkpoint [inference]

positive regulation of DNA damage checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cell cycle phase transition [inference]

regulation of cell cycle checkpoint [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of DNA damage checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of cellular response to stress [inference]

regulation of DNA damage checkpoint [inference]

positive regulation of DNA damage checkpoint

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
nucleus	NAS	20810650
cytoplasm	IDA	23263282
cytoplasm	IBA
TORC1 complex	IDA	23263282
TORC1 complex	IMP	36724785

GO Hierarchy

cellular component

protein-containing complex [inference]

TTT Hsp90 cochaperone complex

intracellular protein-containing complex [inference]

TOR complex [inference]

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	20371770 20801936 20810650 23263282

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

TELO2-interacting protein 1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Armadillo-like helical
Armadillo-type fold
TELO2-interacting protein 1, middle region repeats

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Last updated: December 8, 2025

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Acknowledgements