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Rap guanine nucleotide exchange factor 2

Summary

Gene Symbol

RAPGEF2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9693

PubChem

9693

Alliance of Genome Resources

HGNC:16854

JoGo

RAPGEF2

TogoVar

RAPGEF2

Annotation

Keyword

3D-structure
Alternative splicing
Cell junction
Cell membrane
Cytoplasm
Developmental protein
Differentiation
Endosome
Epilepsy
GTPase activation
Guanine-nucleotide releasing factor
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9Y4G8	Cyclic nucleotide ras GEF Neural RAP guanine nucleotide exchange protein PDZ domain-containing guanine nucleotide exchange factor 1 RA-GEF-1 Ras/Rap1-associating GEF-1
A0A994J7S7	Cyclic nucleotide ras GEF Neural RAP guanine nucleotide exchange protein PDZ domain-containing guanine nucleotide exchange factor 1 RA-GEF-1 Ras/Rap1-associating GEF-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	PMID
MAPK cascade	NAS	10934204
blood vessel development	ISS
neuron migration	ISS
G protein-coupled receptor signaling pathway	IDA	23800469
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA	23800469

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

brain-derived neurotrophic factor receptor signaling pathway

neurotrophin signaling pathway [inference]

nerve growth factor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

neuropeptide signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

intracellular signal transduction

MAPK cascade

small GTPase mediated signal transduction

Ras protein signal transduction

Rap protein signal transduction

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier

establishment of endothelial intestinal barrier

neuron development [inference]

central nervous system neuron development [inference]

forebrain neuron development

cell motility [inference]

cell migration [inference]

neuron migration

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

plasma membrane bounded cell projection organization [inference]

neuron projection development

microvillus organization [inference]

microvillus assembly

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

developmental process [inference]

anatomical structure development [inference]

blood vessel development

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier

establishment of endothelial intestinal barrier

neuron development [inference]

central nervous system neuron development [inference]

forebrain neuron development

system development [inference]

ventricular system development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier

establishment of endothelial intestinal barrier

neuron development [inference]

central nervous system neuron development [inference]

forebrain neuron development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus

response to nerve growth factor [inference]

cellular response to nerve growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus

cellular response to organonitrogen compound [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organic cyclic compound [inference]

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

negative regulation of melanin biosynthetic process

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

negative regulation of melanin biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein serine/threonine kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cAMP-dependent protein kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein serine/threonine kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cAMP-dependent protein kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of secondary metabolic process [inference]

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein serine/threonine kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cAMP-dependent protein kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein serine/threonine kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cAMP-dependent protein kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein serine/threonine kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cAMP-dependent protein kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

regulation of neuron migration [inference]

positive regulation of neuron migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of dendritic cell apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of secondary metabolite biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of dendrite morphogenesis

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendrite morphogenesis [inference]

negative regulation of dendrite morphogenesis

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

regulation of vasculogenesis [inference]

positive regulation of vasculogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

negative regulation of dendrite morphogenesis

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

brain-derived neurotrophic factor receptor signaling pathway

neurotrophin signaling pathway [inference]

nerve growth factor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

neuropeptide signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

intracellular signal transduction

MAPK cascade

small GTPase mediated signal transduction

Ras protein signal transduction

Rap protein signal transduction

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cellular biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

negative regulation of melanin biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein serine/threonine kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cAMP-dependent protein kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein serine/threonine kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cAMP-dependent protein kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of dendritic cell apoptotic process

regulation of leukocyte apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of dendritic cell apoptotic process

regulation of dendritic cell apoptotic process [inference]

positive regulation of dendritic cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of dendritic cell apoptotic process

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

regulation of vasculogenesis [inference]

positive regulation of vasculogenesis

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of leukocyte apoptotic process [inference]

positive regulation of dendritic cell apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of melanin biosynthetic process

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of dendrite morphogenesis

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of dendrite morphogenesis

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

negative regulation of dendrite morphogenesis

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of dendrite morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cell junction assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

regulation of neuron migration [inference]

positive regulation of neuron migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of dendrite morphogenesis

regulation of biological quality [inference]

regulation of synaptic plasticity

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of binding [inference]

positive regulation of protein binding

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of protein serine/threonine kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of cAMP-dependent protein kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of cAMP-dependent protein kinase activity

regulation of binding [inference]

regulation of protein binding [inference]

positive regulation of protein binding

positive regulation of binding [inference]

positive regulation of protein binding

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	11359771 17724123
late endosome	IDA	17724123
cytosol	TAS
cytosol	IDA	22797597
plasma membrane	ISS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

synapse

anchoring junction [inference]

cell-cell junction

tight junction [inference]

bicellular tight junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	IDA	10608883 10801446 12391161 16272156
guanyl-nucleotide exchange factor activity	IBA
GTPase activator activity	IDA	10934204
calcium ion binding	NAS	10934204
protein binding	IPI	10548487 10608844 11168587 11359771 11598133 12391161 15161933 23885123 35271311

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

adrenergic receptor binding [inference]

beta-1 adrenergic receptor binding

protein domain specific binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidic acid binding

diacylglycerol binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

guanyl ribonucleotide binding [inference]

cGMP binding

cyclic nucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

guanyl ribonucleotide binding [inference]

cGMP binding

ion binding [inference]

anion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

guanyl ribonucleotide binding [inference]

cGMP binding

cyclic nucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

guanyl ribonucleotide binding [inference]

cGMP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

guanyl ribonucleotide binding [inference]

cGMP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

rap guanine nucleotide exchange factor

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
small GTPase-mediated signal transduction

Displaying **all 10** entries
InterPro
Cyclic nucleotide-binding domain superfamily
Cyclic nucleotide-binding domain
PDZ domain
PDZ superfamily
Ras guanine nucleotide exchange factor domain superfamily
Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Ras guanine-nucleotide exchange factors catalytic domain
Ras-associating domain
Ras-like guanine nucleotide exchange factor, N-terminal
RmlC-like jelly roll fold

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111694	familial adult myoclonic epilepsy 7	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements