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ER membrane protein complex subunit 2

Summary

Gene Symbol

EMC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9694

PubChem

9694

Alliance of Genome Resources

HGNC:28963

Annotation

Keyword

3D-structure
Acetylation
Endoplasmic reticulum
Membrane
Reference proteome
Repeat
TPR repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15006	Tetratricopeptide repeat protein 35

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA	29242231 33964204
protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IMP	29809151 30415835
tail-anchored membrane protein insertion into ER membrane	IDA	29242231

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

establishment of localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein insertion into membrane [inference]

protein insertion into ER membrane [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	22119785
endoplasmic reticulum	IDA	10942595
endoplasmic reticulum membrane	NAS	29242231
endoplasmic reticulum membrane	IDA	22119785
extrinsic component of endoplasmic reticulum membrane	IDA	32439656

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

EMC complex

endoplasmic reticulum protein-containing complex [inference]

EMC complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

extrinsic component of membrane [inference]

extrinsic component of organelle membrane [inference]

extrinsic component of endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16189514 22119785 25416956 26496610 28514442 30021884 32296183 32439656 33961781 33964204 35271311
membrane insertase activity	IMP	29809151 30415835

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular carrier activity [inference]

protein carrier chaperone [inference]

membrane insertase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ER membrane protein complex subunit 2-A

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
protein folding in endoplasmic reticulum

Displaying **all 3** entries
InterPro
ER membrane protein complex subunit 2-like
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9694	Xenbase:XB-GENE-484487
Mus musculus	66736		MOUSE16124
Rattus norvegicus	362905		RATNO39215
Danio rerio	407073		DANRE09937
Pan troglodytes	472841		PANTR43126
Canis lupus familiaris	481017		CANLF20052
Canis lupus familiaris	612810		CANLF03148
Bos taurus	616813		BOVIN06064
Macaca mulatta	697878		MACMU44795
Monodelphis domestica	100031182		MONDO17022