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endothelin converting enzyme 2

Summary

Gene Symbol

ECE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9718

PubChem

9718

Alliance of Genome Resources

HGNC:13275

Annotation

Keyword

Alternative splicing
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Golgi apparatus
Metal-binding
Metalloprotease
Methyltransferase
Multifunctional enzyme
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P0DPD8
P0DPD6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	TAS
methylation	IEA
protein processing	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

methylation

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardioblast differentiation

stem cell differentiation [inference]

cardioblast differentiation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardioblast differentiation

stem cell differentiation [inference]

cardioblast differentiation

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying **all 4** entries
GO Term	Evidence Code	PMID
transport vesicle membrane	ISS TAS
cytoplasmic vesicle membrane	IDA	11718899
plasma membrane	IBA
Golgi membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

transport vesicle membrane

bounding membrane of organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
metal ion binding	IEA
metalloendopeptidase activity	IBA IDA TAS	11718899
methyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endothelin-converting enzyme

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M13, C-terminal domain
Peptidase M13, N-terminal domain
Peptidase M13, domain 2
Peptidase M13

Ortholog

Displaying entries **71 - 80** of 93 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Aotus nancymaae	110566983			AOTNA25882
Mus musculus	110599584		MGI:6121518	MOUSE18704
Macaca nemestrina	112426413			MACNE06544
Vulpes vulpes	112926261			VULVU20522
Athene cunicularia	113483435			ATHCN11369
Electrophorus electricus	113574664			ELEEL15151
Bos indicus x Bos taurus	113891437			BOBOX29368
Bos indicus x Bos taurus	113891443			BOBOX29368
Vombatus ursinus	114052631			VOMUR24922
Echeneis naucrates	115053304			ECHNA07013

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Last updated: December 9, 2024