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endothelin converting enzyme 2

Summary

Gene Symbol

ECE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9718

PubChem

9718

Alliance of Genome Resources

HGNC:13275

Annotation

Keyword

Alternative splicing
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Golgi apparatus
Metal-binding
Metalloprotease
Methyltransferase
Multifunctional enzyme
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P0DPD8
P0DPD6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cardioblast differentiation
heart development
brain development
peptide hormone processing	IDA	11718899
cell-cell signaling	TAS	11718899

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

methylation

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardioblast differentiation

stem cell differentiation [inference]

cardioblast differentiation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardioblast differentiation

stem cell differentiation [inference]

cardioblast differentiation

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying **all 4** entries
GO Term	Evidence Code	PMID
transport vesicle membrane	ISS TAS
cytoplasmic vesicle membrane	IDA	11718899
plasma membrane	IBA
Golgi membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

transport vesicle membrane

bounding membrane of organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
metal ion binding	IEA
metalloendopeptidase activity	IBA IDA TAS	11718899
methyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endothelin-converting enzyme

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M13, C-terminal domain
Peptidase M13, N-terminal domain
Peptidase M13, domain 2
Peptidase M13

Ortholog

Displaying entries **81 - 90** of 93 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Salmo trutta	115162890			SALTR99331
Salmo trutta	115203796			SALTR77517
Salmo trutta	115205829			SALTR113050
Strigops habroptila	115611209			STRHB11687
Rhinopithecus roxellana	115891985			RHIRO16106
Corvus moneduloides	116448657			CORMO00439
Chelonoidis abingdonii	116838578			CHEAB05749
Rhinolophus ferrumequinum	117011649			RHIFE06546
Balaenoptera musculus	118894391			BALMU17996
Saimiri boliviensis boliviensis	120360085			SAIBB11785

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 9, 2024