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dedicator of cytokinesis 4

Summary

Gene Symbol

DOCK4

Organism

Homo sapiens (human)

External Links

NCBI Gene

9732

PubChem

9732

Alliance of Genome Resources

HGNC:19192

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Cytoplasm
Guanine-nucleotide releasing factor
Phosphoprotein
Proteomics identification
Proto-oncogene
Reference proteome
SH3 domain
SH3-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N1I0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
small GTPase mediated signal transduction	IEA
cell chemotaxis	IMP	20679435
cell chemotaxis	IBA
regulation of postsynapse assembly	IEA
negative regulation of vascular associated smooth muscle contraction	IMP	22158624

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

cell motility [inference]

cell migration [inference]

cell chemotaxis

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleolus	IDA
cytoplasm	IBA
Golgi apparatus	IDA
cytosol	TAS
cytosol	IDA	20679435

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection [inference]

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

nucleolus

postsynapse

cluster of actin-based cell projections [inference]

stereocilium bundle

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	IDA	16464467
guanyl-nucleotide exchange factor activity	IBA
GTPase activator activity	IEA
protein binding	IPI	16464467 20679435 21706016 21988832 31980649 33961781 34819669
SH3 domain binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor tyrosine kinase binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

GTPase binding [inference]

small GTPase binding

protein domain specific binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dedicator of cytokinesis protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cell migration
myoblast fusion
small GTPase-mediated signal transduction

Displaying entries **1 - 10** of 11 in total

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InterPro
C2 DOCK-type domain
C2 domain superfamily
DOCKER domain
DOCKER, Lobe A
DOCKER, Lobe B
DOCKER, Lobe C
Dedicator of cytokinesis, C-terminal, lobe A
Dedicator of cytokinesis, C-terminal, lobe C
Dedicator of cytokinesis, N-terminal domain
Dedicator of cytokinesis, N-terminal, subdomain 1