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Rho GTPase activating protein 32

Summary

Gene Symbol

ARHGAP32

Organism

Homo sapiens (human)

External Links

NCBI Gene

9743

PubChem

9743

Alliance of Genome Resources

HGNC:17399

Annotation

Keyword

3D-structure
Alternative splicing
Cell projection
Cytoplasm
Endoplasmic reticulum
Endosome
GTPase activation
Golgi apparatus
Membrane
Methylation
Phosphoprotein
Reference proteome
SH3 domain
Synapse

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q86T64
A7KAX9	Brain-specific Rho GTPase-activating protein GAB-associated Cdc42/Rac GTPase-activating protein GC-GAP GTPase regulator interacting with TrkA Rho-type GTPase-activating protein 32 Rho/Cdc42/Rac GTPase-activating protein RICS RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling p200RhoGAP p250GAP

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
regulation of small GTPase mediated signal transduction	TAS
small GTPase mediated signal transduction	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

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GO Term	Evidence Code	PMID
Golgi apparatus	IBA IDA
cell cortex	IBA
postsynaptic density	ISS
endoplasmic reticulum membrane	IEA
nucleoplasm	IBA IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex

cytosol

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

postsynapse [inference]

dendritic spine

Displaying **all 3** entries
GO Term	Evidence Code	PMID
GTPase activator activity	IBA TAS
protein binding	IPI	12788081 15778465 25416956 29892012 31980649 32296183 35044719 36931259
phosphatidylinositol phosphate binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GTPase activator

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Rho GTPase activation protein
Rho GTPase-activating protein domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	35267		FB:FBgn0032821
Rattus norvegicus	315530		RGD:1305267	RATNO39962
Mus musculus	330914		MGI:2450166	MOUSE60785
Xenopus laevis	444120		Xenbase:XB-GENE-1002479
Pan troglodytes	451663	9598_0:002e48		PANTR04725
Canis lupus familiaris	489283			CANLF15090
Bos taurus	506260			BOVIN23106
Danio rerio	562449		ZFIN:ZDB-GENE-060503-918
Danio rerio	569434		ZFIN:ZDB-GENE-091204-147	DANRE21456
Macaca mulatta	718464			MACMU09388

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements