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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
lysine methyltransferase 2B
Summary
- Gene Symbol
-
- KMT2B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Chromatin regulator
- DNA-binding
- Disease variant
- Dystonia
- Intellectual disability
- Isopeptide bond
- Methyltransferase
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- S-adenosyl-L-methionine
- Transcription regulation
- Ubl conjugation
- Zinc-finger
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9UMN6 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| chromatin remodeling | ||
| positive regulation of transcription, DNA-templated | ||
| positive regulation of DNA-templated transcription | ||
| methylation |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleoplasm | ||
| histone methyltransferase complex | ||
| MLL1/2 complex | ||
| nucleus |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| histone H3K4 trimethyltransferase activity | ||
| protein binding | ||
| zinc ion binding | ||
| histone H3K4 monomethyltransferase activity | ||
| histone H3K4 methyltransferase activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Histone-lysine n-methyltransferase
- Functional Category
-
- C: Energy production and conversion
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| methylation |
| transferase activity |
| InterPro |
|---|
| Post-SET domain |
| SET domain superfamily |
| SET domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | |
| DOID:0060936 | dystonia 28 childhood-onset | |
| DOID:10283 | prostate cancer | |
| DOID:1612 | breast cancer | |
| DOID:1682 | congenital heart disease | |
| DOID:684 | hepatocellular carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 41737 | FB:FBgn0003862 | |||
| 75410 | MGI:109565 | MOUSE55490 | ||
| 448597 | Xenbase:XB-GENE-5805214 | |||
| 455959 | 9598_0:004f3d | PANTR18021 | ||
| 560856 | ZFIN:ZDB-GENE-060503-376 | |||
| 566825 | ZFIN:ZDB-GENE-080521-1 | |||
| 612999 | CANLF01190 | |||
| 718835 | MACMU17872 | |||
| 785776 | BOVIN10903 | |||
| 100059802 | HORSE00929 |
