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SET domain bifurcated histone lysine methyltransferase 1

Summary

Gene Symbol

SETDB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9869

PubChem

9869

Alliance of Genome Resources

HGNC:10761

Annotation

Keyword

3D-structure
Alternative splicing
Chromatin regulator
Chromosome
Coiled coil
Cytoplasm
Isopeptide bond
Metal-binding
Methylation
Methyltransferase
Nucleus
Phosphoprotein
Reference proteome
Repeat
Repressor
S-adenosyl-L-methionine
Transcription regulation
Ubl conjugation
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15047	ERG-associated protein with SET domain Histone H3-K9 methyltransferase 4 Lysine N-methyltransferase 1E SET domain bifurcated 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
DNA methylation-dependent heterochromatin formation	IMP	24623306 27732843
negative regulation of gene expression	IDA	39096901
negative regulation of gene expression	IBA
methylation	IEA
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

GO Hierarchy

biological process

metabolic process [inference]

methylation

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

heterochromatin organization

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of heterochromatin formation [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

regulation of DNA methylation-dependent heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA biosynthetic process [inference]

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA biosynthetic process [inference]

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of heterochromatin formation [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

regulation of DNA methylation-dependent heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA biosynthetic process [inference]

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA biosynthetic process [inference]

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of heterochromatin formation [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

regulation of DNA methylation-dependent heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA biosynthetic process [inference]

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA biosynthetic process [inference]

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA biosynthetic process [inference]

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromatin organization [inference]

positive regulation of heterochromatin organization [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of cellular process [inference]

retrotransposon silencing [inference]

retrotransposon silencing by heterochromatin formation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of viral process [inference]

negative regulation of viral genome replication [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of viral process [inference]

negative regulation of viral process [inference]

negative regulation of viral genome replication [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of viral life cycle [inference]

regulation of viral genome replication [inference]

negative regulation of viral genome replication [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA biosynthetic process [inference]

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of heterochromatin formation [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

regulation of DNA methylation-dependent heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of RNA biosynthetic process [inference]

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromatin organization [inference]

positive regulation of heterochromatin organization [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

negative regulation of cellular process [inference]

retrotransposon silencing [inference]

retrotransposon silencing by heterochromatin formation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromatin organization [inference]

positive regulation of heterochromatin organization [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

regulation of chromosome organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromatin organization [inference]

positive regulation of heterochromatin organization [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromatin organization [inference]

positive regulation of heterochromatin organization [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

regulation of chromatin organization [inference]

regulation of heterochromatin organization [inference]

regulation of heterochromatin formation [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

regulation of DNA methylation-dependent heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

positive regulation of heterochromatin organization [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

positive regulation of chromatin organization [inference]

positive regulation of heterochromatin organization [inference]

positive regulation of heterochromatin formation [inference]

positive regulation of DNA methylation-dependent heterochromatin formation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	27732843
nucleus	IMP	27732843
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 11 in total

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3

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GO Term	Evidence Code	PMID
DNA binding	IEA
chromatin binding	IDA	27029610
protein binding	IPI	16682412 17577629 20871592 21170338 23034801 24705354 26022416 27029610 27732843 29774127 32051553 32296183 32814053 33961781 37179361
zinc ion binding	IEA
histone H3K9 methyltransferase activity	IDA	14536086

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

N-methyltransferase activity [inference]

lysine N-methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K9 methyltransferase activity

protein methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K9 methyltransferase activity

histone methyltransferase activity [inference]

histone H3 methyltransferase activity

histone H3K9 methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

lysine N-methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K9 methyltransferase activity

catalytic activity, acting on a protein [inference]

protein methyltransferase activity [inference]

protein-lysine N-methyltransferase activity [inference]

histone H3K9 methyltransferase activity

histone methyltransferase activity [inference]

histone H3 methyltransferase activity

histone H3K9 methyltransferase activity

histone modifying activity [inference]

histone methyltransferase activity [inference]

histone H3 methyltransferase activity

histone H3K9 methyltransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

promoter-specific chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Histone-lysine n-methyltransferase

Functional Category

C: Energy production and conversion
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
methylation
transferase activity

Displaying **all 3** entries
InterPro
Post-SET domain
SET domain superfamily
SET domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 76** of 76 in total

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Species	Gene ID	Orthologous MAtrix
Chelonoidis abingdonii	116817630	CHEAB14699
Rhinolophus ferrumequinum	117014537	RHIFE26446
Scophthalmus maximus	118299766	SCOMX16092
Balaenoptera musculus	118897508	BALMU23804
Panthera leo	122228685	PANLE11731
Ursus americanus	123787733	URSAM22426

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements