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3-hydroxy-3-methylglutaryl-CoA lyase like 1

Summary

Gene Symbol

HMGCLL1

Organism

Pan paniscus (pygmy chimpanzee)

External Links

NCBI Gene: 100990466
KEGG Gene ID: pps:100990466
PubChem: 100990466

Annotation

Keyword

Metal-binding
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2R9ALA9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
ketone body biosynthetic process	IEA	30032202
leucine catabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

ketone body biosynthetic process

small molecule biosynthetic process [inference]

ketone body biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

cellular biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

cellular biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA	30032202
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	PMID
hydroxymethylglutaryl-CoA lyase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

oxo-acid-lyase activity [inference]

hydroxymethylglutaryl-CoA lyase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01640

Name

hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]

References

17692550

Rhea

(3S)-hydroxy-3-methylglutaryl-CoA

acetoacetate + acetyl-CoA

Enzyme

4.1.3.4

PMID

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103179011		CALMI16896
Danio rerio	571388		DANRE05651
Electrophorus electricus	113585405		ELEEL06219
Salmo salar	106613523		SALSA11002
Salmo trutta	115153431		SALTR08764
Salmo trutta	115201598		SALTR101610
Oreochromis niloticus	100697128		ORENI12174
Sparus aurata	115596395		SPAAU10345
Chrysemys picta bellii	101931589		CHRPI02283
Crocodylus porosus	109311742		CROPO09865

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024