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CEA cell adhesion molecule 5

Summary

Gene Symbol

CEACAM5

Aliases

CD66e

Organism

Homo sapiens (human)

External Links

NCBI Gene

1048

HGNC

1817

KEGG Gene ID

hsa:1048

PubChem

1048

Alliance of Genome Resources

HGNC:1817

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Cell adhesion
Cell membrane
Disulfide bond
GPI-anchor
Immunoglobulin domain
Oncogene
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q53G30
A0A024R0K5
P06731	Carcinoembryonic antigen Meconium antigen 100

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA IMP	2803308
negative regulation of myotube differentiation	IDA	10931872 8408226
negative regulation of apoptotic process	IDA	11448920
homophilic cell adhesion via plasma membrane adhesion molecules	IMP	2803308
negative regulation of anoikis	IDA	10910050

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of anoikis

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of striated muscle cell differentiation [inference]

regulation of myotube differentiation [inference]

negative regulation of myotube differentiation

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of anoikis

regulation of anoikis [inference]

negative regulation of anoikis

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of anoikis

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of striated muscle cell differentiation [inference]

regulation of myotube differentiation [inference]

negative regulation of myotube differentiation

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of anoikis

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

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GO Term	Evidence Code	PMID
extracellular region
cell surface	IBA IC IDA	2317824 2803308
plasma membrane	IDA TAS	10864933 10931872
side of membrane	IEA
membrane	IDA	2317824

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
GPI anchor binding	IMP	10931872
protein homodimerization activity	IDA	18086185
protein binding	IPI	27489282
identical protein binding	IDA IPI	10864933 18086185 26483485

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

GPI anchor binding

glycolipid binding [inference]

GPI anchor binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

GPI anchor binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000105388

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K06499

Name

carcinoembryonic antigen-related cell adhesion molecule

References

Disease

Disease Ontology

Displaying entries **1 - 10** of **340** in total

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050156	idiopathic pulmonary fibrosis	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050424	familial adenomatous polyposis	DisGeNET DisGeNET
DOID:0050430	multiple endocrine neoplasia type 2A	DisGeNET DisGeNET DisGeNET
DOID:0050547	familial medullary thyroid carcinoma	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET
DOID:0050646	distal arthrogryposis	DisGeNET
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0050848	obstructive sleep apnea	DisGeNET

Ortholog

Displaying **all 10** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	114465	ZFIN:ZDB-GENE-010724-14
Xenopus tropicalis	100145081	Xenbase:XB-GENE-5920801
Xenopus tropicalis	101730286	Xenbase:XB-GENE-22169429
Pan paniscus	100973847		PANPA20582
Pan troglodytes	456062		PANTR18389
Pongo abelii	100436113		PONAB14141
Mus musculus	26365	MGI:1347245
Mus musculus	26367	MGI:1347246
Rattus norvegicus	81613	RGD:67396
Nomascus leucogenys	100606339		NOMLE12412

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements