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beta-1,3-glucuronyltransferase 2

Summary

Gene Symbol

B3GAT2

Aliases

GlcAT-S
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
glucuronosyltransferase S

Organism

Homo sapiens (human)

External Links

NCBI Gene

135152

GGDB ID

gg156

HGNC

922

mRNA

NM_080742

map

6q13

Protein

NP_542780

OMIM

607497

KEGG Gene ID

hsa:135152

PubChem

135152

Alliance of Genome Resources

HGNC:922

Annotation

Keyword

3D-structure
Glycoprotein
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NPZ5	Beta-1,3-glucuronyltransferase 2 GlcAT-D UDP-glucuronosyltransferase S

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IBA
chondroitin sulfate proteoglycan biosynthetic process	IBA
protein glycosylation	IEA
carbohydrate biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

carbohydrate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

carbohydrate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

carbohydrate biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein glycosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

carbohydrate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

proteoglycan biosynthetic process [inference]

chondroitin sulfate proteoglycan biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA ISS
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

glucuronosyltransferase activity [inference]

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

hexosyltransferase activity [inference]

glucuronosyltransferase activity [inference]

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg156

Gene Symbol

B3GAT2

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcA	G00055MO	G10271ZL	15470230

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcA	G00055MO	G10271ZL	15470230

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_072131	NM_022609
Mus musculus	NP_742122	NM_172124

KEGG BRITE Database

Orthology

K10157

Name

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 [EC:2.4.1.135]

References

Rhea

UDP-α-D-glucuronate

H⁺ + UDP

Enzyme

2.4.1.135

PMID

18400750

UDP-α-D-glucuronate

H⁺ + UDP

Enzyme

2.4.1.135

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:2452	thrombophilia	DisGeNET
DOID:5419	schizophrenia	DisGeNET Alliance of Genome Resources
DOID:9206	Barrett's esophagus	DisGeNET Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	174517	WB:WBGene00005026
Caenorhabditis elegans	183560	WB:WBGene00008160
Caenorhabditis elegans	183771	WB:WBGene00008293
Caenorhabditis elegans	184025	WB:WBGene00008479
Caenorhabditis elegans	188329	WB:WBGene00011650
Caenorhabditis elegans	188533	WB:WBGene00011781
Caenorhabditis elegans	4363062	WB:WBGene00019546
Drosophila melanogaster	251900	FB:FBgn0066114
Callorhinchus milii	103185598		CALMI32639
Danio rerio	445060	ZFIN:ZDB-GENE-040801-191	DANRE05392

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024