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alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

Summary

Gene Symbol

MGAT5B

Aliases

FLJ25132
GnT-IX
GnT-VB

Organism

Homo sapiens (human)

External Links

NCBI Gene

146664

GGDB ID

gg131

HGNC

24140

mRNA

NM_144677

map

17q25.3

Protein

NP_653278

OMIM

612441

KEGG Gene ID

hsa:146664

PubChem

146664

Alliance of Genome Resources

HGNC:24140

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3V5L5	Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B GlcNAc-T Vb Mannoside acetylglucosaminyltransferase 5B N-acetylglucosaminyl-transferase Vb N-acetylglucosaminyltransferase IX

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IBA
protein O-linked glycosylation via serine	IDA	19846580

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IBA
Golgi membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23088713
manganese ion binding	IDA	19846580
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	IBA IDA	19846580

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
protein N-linked glycosylation
transferase activity

Displaying 1 entry
InterPro
Glycosyltransferase family 18

GlycoGene Database (GGDB)

GGDB ID

gg131

Gene Symbol

MGAT5B

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G39213VZ	Asn-X	G10219AA	Asn-X	12941944

Displaying **all 4** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G39213VZ	Asn-X	G10219AA	Asn-X	12941944
UDP-GlcNAc	G85856KC	O-benzyl	G56868BH	O-benzyl	19846580
UDP-GlcNAc	G39213VZ	Asialo-galacto-biantennary	G83717YJ	Asialo-galacto-biantennary	19846580
UDP-GlcNAc	G85856KC	Ac-VEP[T*]AV-NH2[alpha]-dystroglycan	G56868BH	Ac-VEP[T*]AV-NH2[alpha]-dystroglycan	19846580

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GlcNAc	G49108TO		19846580

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_221136	XM_221136
Mus musculus	NP_766536	NM_172948

KEGG BRITE Database

Orthology

K09661

Name

mannosyl alpha-1,6-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B [EC:2.4.1.-]

References

12941944

Reactions

Displaying **all 6** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07621	2.4.1.-	G85856KC	G56868BH
R07622	2.4.1.-	G39213VZ	G10219AA
R07625	2.4.1.-	G88380UG	G83717YJ
R07623	2.4.1.-	G39213VZ	G88380UG
R05991	2.4.1.155	G29011JC	G20030CU
R07624	2.4.1.-	G10219AA	G83717YJ

Rhea

RHEA:16921

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.155

PMID

Ortholog

Displaying entries **1 - 10** of **107** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172360		WB:WBGene00001627
Mus musculus	268510		MGI:3606200	MOUSE04039
Rattus norvegicus	303693		RGD:1305188	RATNO00803
Canis lupus familiaris	483337			CANLF18409
Macaca mulatta	708299			MACMU15916
Pan troglodytes	740411	9598_0:0043e8		PANTR15521
Bos taurus	785213			BOVIN13907
Monodelphis domestica	100027070			MONDO14628
Equus caballus	100058438			HORSE03805
Taeniopygia guttata	100226604			TAEGU06899

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements