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heparan sulfate-glucosamine 3-sulfotransferase 5

Summary

Gene Symbol

HS3ST5

Aliases

3-OST-5

Organism

Homo sapiens (human)

External Links

NCBI Gene

222537

GGDB ID

gg019

HGNC

19419

mRNA

NM_153612

map

6q22.31

Protein

NP_705840

OMIM

609407

KEGG Gene ID

hsa:222537

PubChem

222537

Alliance of Genome Resources

HGNC:19419

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Golgi apparatus
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IZT8	Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein sulfation	IDA	12138164
heparan sulfate proteoglycan biosynthetic process, enzymatic modification	TAS
heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IDA	12138164
regulation of viral entry into host cell	IDA	12138164
negative regulation of coagulation	IDA	12138164

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

protein modification process [inference]

protein sulfation

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

sulfation [inference]

protein sulfation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

protein modification process [inference]

protein sulfation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

protein modification process [inference]

protein sulfation

macromolecule modification [inference]

protein modification process [inference]

protein sulfation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

protein modification process [inference]

protein sulfation

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

sulfation [inference]

protein sulfation

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation

regulation of viral process [inference]

regulation of viral life cycle [inference]

regulation of viral entry into host cell

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

negative regulation of coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
membrane	NAS	12138164

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12138164
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	TAS
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IDA	12138164 12740361
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IBA
3'-phosphoadenosine 5'-phosphosulfate binding	NAS	12138164

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity [inference]

heparan sulfate sulfotransferase activity [inference]

[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ion binding [inference]

anion binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

sulfur compound binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heparan sulfate glucosamine 3-O-sulfotransferase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
sulfotransferase activity
transferase activity

Displaying **all 3** entries
InterPro
Heparan sulfate sulfotransferase
P-loop containing nucleoside triphosphate hydrolase
Sulfotransferase domain

GlycoGene Database (GGDB)

GGDB ID

gg019

Gene Symbol

HS3ST5

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Rattus norvegicus	XP_228219	XM_228219
Mus musculus	XP_356462	XM_356462
Drosophila melanogaster	NP_788409	NM_176229

KEGG BRITE Database

Orthology

K08104

Name

[heparan sulfate]-glucosamine 3-sulfotransferase 5 [EC:2.8.2.23]

References

12138164

Rhea

RHEA:15461

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

PMID

Ortholog

Displaying entries **1 - 10** of **115** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9957	FB:FBgn0053147
Drosophila melanogaster	15476	FB:FBgn0053147
Xenopus tropicalis	37161	Xenbase:XB-GENE-5795358
Drosophila melanogaster	84406	FB:FBgn0053147
Xenopus tropicalis	222537	Xenbase:XB-GENE-5795358
Rattus norvegicus	294449	Xenbase:XB-GENE-5795358	RATNO21508
Mus musculus	319415	Xenbase:XB-GENE-5795358	MOUSE00382
Canis lupus familiaris	481968		CANLF03080
Caenorhabditis elegans	496940	WB:WBGene00002030
Bos taurus	540355		BOVIN35506

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Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

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Acknowledgements