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heparan sulfate-glucosamine 3-sulfotransferase 5

Summary

Gene Symbol

HS3ST5

Aliases

3-OST-5

Organism

Homo sapiens (human)

External Links

NCBI Gene

222537

GGDB ID

gg019

HGNC

19419

mRNA

NM_153612

map

6q22.31

Protein

NP_705840

OMIM

609407

KEGG Gene ID

hsa:222537

PubChem

222537

Alliance of Genome Resources

HGNC:19419

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Golgi apparatus
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IZT8	Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein sulfation	IDA	12138164
negative regulation of coagulation	IDA	12138164
heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IDA TAS	12138164
regulation of viral entry into host cell	IDA	12138164

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

protein modification process [inference]

protein sulfation

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

sulfation [inference]

protein sulfation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

protein modification process [inference]

protein sulfation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

protein modification process [inference]

protein sulfation

macromolecule modification [inference]

protein modification process [inference]

protein sulfation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

protein modification process [inference]

protein sulfation

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

sulfation [inference]

protein sulfation

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation

regulation of viral process [inference]

regulation of viral life cycle [inference]

regulation of viral entry into host cell

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

negative regulation of coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane		12138164
Golgi membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12138164
3'-phosphoadenosine 5'-phosphosulfate binding		12138164
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IBA IDA TAS	12138164 12740361

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity [inference]

heparan sulfate sulfotransferase activity [inference]

[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ion binding [inference]

anion binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

sulfur compound binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg019

Gene Symbol

HS3ST5

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Rattus norvegicus	XP_228219	XM_228219
Drosophila melanogaster	NP_788409	NM_176229
Mus musculus	XP_356462	XM_356462

KEGG BRITE Database

Orthology

K08104

Name

[heparan sulfate]-glucosamine 3-sulfotransferase 5 [EC:2.8.2.23]

References

12138164

Rhea

RHEA:15461

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1909	melanoma	DisGeNET
DOID:5419	schizophrenia	DisGeNET
DOID:8923	skin melanoma	DisGeNET

Ortholog

Displaying entries **1 - 10** of **110** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	185573	WB:WBGene00002030
Drosophila melanogaster	37161	FB:FBgn0053147
Callorhinchus milii	103182576		CALMI25303
Latimeria chalumnae	102345335		LATCH07634
Lepisosteus oculatus	102695568		LEPOC00960
Astyanax mexicanus	103029341		ASTMX12920
Esox lucius	105017884		ESOLU52708
Salmo salar	106571321		SALSA42862
Salmo salar	106607731		SALSA132706
Salmo trutta	115174903		SALTR54029

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements