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LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Summary

Gene Symbol

LFNG

Aliases

SCDO3

Organism

Homo sapiens (human)

External Links

NCBI Gene

3955

GGDB ID

gg133

HGNC

6560

mRNA

XM_166539

map

7p22

Protein

Q8NES3

OMIM

602576

KEGG Gene ID

hsa:3955

PubChem

3955

Alliance of Genome Resources

HGNC:6560

Annotation

Keyword

Alternative splicing
Developmental protein
Disease variant
Disulfide bond
Dwarfism
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NES3	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
T cell differentiation	ISS
compartment pattern specification	IEA
ovarian follicle development	IEA
somitogenesis	ISS
positive regulation of meiotic cell cycle	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

T cell differentiation

T cell activation [inference]

T cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

T cell differentiation

T cell activation [inference]

T cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

T cell differentiation

reproductive process [inference]

developmental process involved in reproduction [inference]

ovarian follicle development

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

T cell differentiation

T cell activation [inference]

T cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

segmentation [inference]

somitogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

ovarian follicle development

anatomical structure morphogenesis [inference]

animal organ morphogenesis

anatomical structure formation involved in morphogenesis [inference]

somitogenesis

anatomical structure development [inference]

ovarian follicle development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

T cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of Notch signaling pathway

regulation of Notch signaling pathway involved in somitogenesis [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of Notch signaling pathway

regulation of Notch signaling pathway involved in somitogenesis [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of somitogenesis

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of Notch signaling pathway

regulation of Notch signaling pathway involved in somitogenesis [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway involved in somitogenesis

regulation of cell cycle [inference]

positive regulation of cell cycle [inference]

positive regulation of meiotic cell cycle

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle

regulation of multicellular organismal process [inference]

regulation of somitogenesis

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	NAS	10341080
extracellular vesicle	HDA	24769233
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA IDA ISS TAS	10935626

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000106003

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg133

Gene Symbol

LFNG

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G96881BQ	G26238GL	10935626

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G96881BQ	G26238GL	10935626

Displaying **all 6** entries
Donor	Acceptor	Reference
UDP-Gal	G96881BQ	10935626
UDP-GalNAc	G96881BQ	10935626
UDP-Glc	G96881BQ	10935626
UDP-GlcNAc	G65889KE	10935626
UDP-GlcNAc	G96881BQ	10935626
UDP-GlcNAc	G71142DF	10935626

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_596884	NM_133393
Mus musculus	NP_032520	NM_008494

KEGG BRITE Database

Orthology

K05948

Name

fringe [EC:2.4.1.222]

References

9187150

Rhea

RHEA:70531

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.222

PMID

RHEA:70511

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.222

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 35 in total

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DO ID	Disease Name	Source
DOID:0050568	spondylocostal dysostosis	DisGeNET DisGeNET DisGeNET
DOID:0060249	scoliosis	DisGeNET
DOID:0060320	inguinal hernia	DisGeNET
DOID:0060321	umbilical hernia	DisGeNET
DOID:0060327	omphalocele	DisGeNET
DOID:0080073	spina bifida occulta	DisGeNET
DOID:0110213	isolated cleft palate	DisGeNET
DOID:0112361	spondylocostal dysostosis 3	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:10426	Klippel-Feil syndrome	DisGeNET DisGeNET
DOID:1059	intellectual disability	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 44 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000008	Abnormal morphology of female internal genitalia
HP:0000023	Inguinal hernia
HP:0000028	Cryptorchidism
HP:0000047	Hypospadias
HP:0000069	Abnormality of the ureter
HP:0000175	Cleft palate
HP:0000252	Microcephaly
HP:0000256	Macrocephaly
HP:0000269	Prominent occiput

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:2311	autosomal recessive spondylocostal dysostosis
OMIM:609813	spondylocostal dysostosis 3, autosomal recessive

PubChem Disease

MedGen Diseases

Spondylocostal dysostosis 3, autosomal recessive

OMIM Phenotypes

SPONDYLOCOSTAL DYSOSTOSIS 3, AUTOSOMAL RECESSIVE; SCDO3

KEGG Diseases

Spondylocostal dysostosis

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	40314	FB:FBgn0011591
Callorhinchus milii	103189782		CALMI42240
Latimeria chalumnae	102347945		LATCH17113
Danio rerio	30158	ZFIN:ZDB-GENE-980605-16	DANRE31429
Astyanax mexicanus	103025168		ASTMX04956
Ictalurus punctatus	108257411		ICTPU18982
Electrophorus electricus	113571376		ELEEL03889
Salmo salar	106601125		SALSA34804
Salmo salar	106607332		SALSA34804
Salmo trutta	115171151		SALTR92264

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements