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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

Summary

Gene Symbol

ST8SIA1

Aliases

ST8Sia I

Organism

Homo sapiens (human)

External Links

NCBI Gene

6489

GGDB ID

gg062

HGNC

10869

mRNA

NM_003034

map

12p12.1-p11.2

Protein

NP_003025

OMIM

601123

KEGG Gene ID

hsa:6489

PubChem

6489

Alliance of Genome Resources

HGNC:10869

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Sphingolipid metabolism
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92185	Alpha-2,8-sialyltransferase 8A Ganglioside GD3 synthase Ganglioside GT3 synthase Sialyltransferase 8A Sialyltransferase St8Sia I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cellular response to heat	IEA
carbohydrate metabolic process	TAS	8195250
N-glycan processing	IBA
glycosphingolipid biosynthetic process	TAS	8195250
oligosaccharide metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular process [inference]

cell population proliferation [inference]

epithelial cell proliferation

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

response to stimulus [inference]

response to stress [inference]

response to heat [inference]

cellular response to heat

cellular response to stress [inference]

cellular response to heat

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

cellular response to heat

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	TAS	8195250
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IBA IDA TAS	18348864 22885356 8706663
protein binding	IPI	32814053
sialyltransferase activity	TAS	8195250

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000111728

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg062

Gene Symbol

ST8SIA1

Reactions

Displaying **all 2** entries
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G91237TK	G98544DH	8195250
CMP-Neu5Ac	G98544DH		8631981

Displaying **all 6** entries
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G98544DH		8631981
CMP-Neu5Ac	G03277YI	G81983KG	8910600
CMP-Neu5Ac	G46677TE	G68110IF	8910600
CMP-Neu5Ac	G01767JJ	G70647TI	8910600
CMP-Neu5Ac	G40183QN	G18625KA	8910600
CMP-Neu5Ac	G91237TK	G98544DH	8195250 8910600

Displaying 1 entry
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G98544DH		8910600

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_036945	NM_012813
Mus musculus	NP_035504	NM_011374

KEGG BRITE Database

Orthology

K03371

Name

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A) [EC:2.4.3.8]

References

8058740

Reactions

Displaying **all 4** entries
KEGG Reaction	Enzyme	Acceptor	Product
R13175	2.4.3.8	G32254QI	G50116PC
R05940	2.4.3.8	G91237TK	G98544DH
R05947	2.4.3.8	G98544DH	G93899SO
R06032	2.4.3.8	G01767JJ	G70647TI

Rhea

RHEA:19313

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl derivative + H⁺ + CMP

Enzyme

2.4.3.8

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 48 in total

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DO ID	Disease Name	Source
DOID:0060262	gallbladder disease	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET
DOID:0110039	Alzheimer's disease 7	DisGeNET
DOID:0110041	Alzheimer's disease 8	DisGeNET
DOID:0110043	Alzheimer's disease 10	DisGeNET
DOID:0110044	Alzheimer's disease 11	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000464
Gene Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103181078		CALMI21900
Danio rerio	553210	ZFIN:ZDB-GENE-051005-1	DANRE33846
Astyanax mexicanus	103035159		ASTMX02003
Ictalurus punctatus	108279455		ICTPU12464
Ictalurus punctatus	108279490		ICTPU13124
Electrophorus electricus	113584008		ELEEL31963
Salmo salar	106609639		SALSA52694
Salmo trutta	115180086		SALTR54997
Salmo trutta	115199122		SALTR65770
Gadus morhua	115532215		GADMO24562

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements