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alkylglycerone phosphate synthase

Summary

Gene Symbol

AGPS

Aliases

ADAP-S
ADAS
ADHAPS
ADPS
ALDHPSY

Organism

Homo sapiens (human)

External Links

NCBI Gene

8540

HGNC

327

KEGG Gene ID

hsa:8540

PubChem

8540

Alliance of Genome Resources

HGNC:327

Annotation

Keyword

Acetylation
Cataract
Disease variant
Dwarfism
FAD
Lipid biosynthesis
Membrane
Peroxisome
Phosphoprotein
Proteomics identification
Reference proteome
Rhizomelic chondrodysplasia punctata
Transferase
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7Z3Q4
O00116	Aging-associated gene 5 protein Alkylglycerone-phosphate synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
ether lipid biosynthetic process	IEA ISS
lipid biosynthetic process	IBA IDA	9553082

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

small molecule metabolic process [inference]

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytosol
membrane	HDA	19946888
peroxisome	IBA IDA	10415121 9553082
mitochondrion	HDA	20833797
peroxisomal membrane	HDA	21525035

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle membrane [inference]

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
alkylglycerone-phosphate synthase activity	IBA IDA	10415121 8399344 9553082
protein binding	IPI	25416956 31515488 32296183
FAD binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

alkylglycerone-phosphate synthase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000018510

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00803

Name

alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26]

References

Rhea

a long chain fatty alcohol + a 1-acylglycerone 3-phosphate

H⁺ + a long-chain fatty acid + 1-O-alkylglycerone 3-phosphate

Enzyme

2.5.1.26

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 47 in total

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DO ID	Disease Name	Source
DOID:0050585	congenital generalized lipodystrophy	DisGeNET
DOID:0060292	X-linked chondrodysplasia punctata 1	DisGeNET
DOID:0060293	autosomal dominant chondrodysplasia punctata	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0080476	peroxisome biogenesis disorder 1A	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET
DOID:0110039	Alzheimer's disease 7	DisGeNET
DOID:0110041	Alzheimer's disease 8	DisGeNET

The Human Phenotype Ontology

Displaying **all 7** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0001508	Failure to thrive
HP:0003097	Short femur
HP:0005792	Short humerus
HP:0008873	Disproportionate short-limb short stature
HP:0008905	Rhizomelia
HP:0010655	Epiphyseal stippling

Displaying 1 entry
Disease ID	Disease Name
OMIM:600121	rhizomelic chondrodysplasia punctata type 3

PubChem Disease

GHR Health Conditions

Rhizomelic chondrodysplasia punctata

MedGen Diseases

Rhizomelic chondrodysplasia punctata type 3

OMIM Phenotypes

RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 3; RCDP3

KEGG Diseases

Rhizomelic chondrodysplasia punctata

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002031
Gene Name: alkylglycerone phosphate synthase

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175192	WB:WBGene00000081
Drosophila melanogaster	36669	FB:FBgn0033983
Latimeria chalumnae	102349851		LATCH07213
Danio rerio	386801	ZFIN:ZDB-GENE-031118-14	DANRE44204
Ictalurus punctatus	108266713		ICTPU30918
Electrophorus electricus	113582330		ELEEL28837
Salmo trutta	115155483		SALTR11032
Salmo trutta	115160788		SALTR16146
Oreochromis niloticus	100696533		ORENI21142
Sparus aurata	115587811		SPAAU29292

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024