GlyCosmos Portal

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Prothrombin

Summary

UniProt ID

A0A2K6DHV7

Gene Symbol

F2

Organism

Macaca nemestrina (pig-tailed macaque)

External Links

Annotation

Keyword

Acute phase
Blood coagulation
Cleavage on pair of basic residues
Disulfide bond
Gamma-carboxyglutamic acid
Kringle
Reference proteome
Serine protease
Signal

Gene Ontology (GO)

Displaying entries **11 - 20** of 26 in total

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GO Term
negative regulation of proteolysis
negative regulation of astrocyte differentiation
negative regulation of cytokine production involved in inflammatory response
ligand-gated ion channel signaling pathway
positive regulation of reactive oxygen species metabolic process
positive regulation of protein localization to nucleus
cytolysis by host of symbiont cells
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of protein phosphorylation

Displaying **all 4** entries
GO Term
collagen-containing extracellular matrix
extracellular space
endoplasmic reticulum lumen
external side of plasma membrane

Displaying **all 6** entries
GO Term
heparin binding
serine-type endopeptidase activity
lipopolysaccharide binding
thrombospondin receptor activity
signaling receptor binding
calcium ion binding

Annotation information from UniProt.

Sequence

MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQVFLAPQQALSLLQRVRRASSGFLEEVFKGNLERECVEETCSYEEAFEALESSTATADWGGVSAGNCAEDLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRREECSIPVCGQDQVTVAMTPRSSVNLSLPSEECVPDRGRQYQGHLAVTTHGLPCLAWASAQAKALSKHQDFDSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFEYCDLNYCEEAVDEETGDGLGEDPDRAIEGRTATSEYQTFFDPRTFGLGEADCGLRPLFEKKSLEDKTEGELLESYIDGRIVEGWDAEIGMSPWCVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPITFSDYIHPVCLPDRETAASLFQAGYKGRVTGWGNLKETWTTNVGKVQPSVLQVVNLPIVERSVCKDSTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKNPLNKRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
112	N-linked (GlcNAc...) (complex) asparagine	UniProt
134	N-linked (GlcNAc...) (complex) asparagine	UniProt
404	N-linked (GlcNAc...) (complex) asparagine	UniProt