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MIRAGE
Proton-coupled folate transporter
Summary
- UniProt ID
- F1NJ67
- Gene Symbol
-
- PCFT
- SLC46A1
- Gene ID
- 417569
- Organism
- Gallus gallus (chicken)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Cytoplasm
- Disulfide bond
- Endosome
- Folate-binding
- Glycoprotein
- Reference proteome
- Symport
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| endosome |
| basolateral plasma membrane |
| apical plasma membrane |
| endosome membrane |
| GO Term |
|---|
| folate import across plasma membrane |
| transmembrane transport |
| GO Term |
|---|
| transmembrane transporter activity |
| folic acid binding |
| methotrexate transmembrane transporter activity |
| folic acid:proton symporter activity |
Sequence
MAAPSDPPTAATPPAPPPPARRCLLAPSVEPLLFLATLALGLQVPLATQYLWDRLGAERGYVGPNASSPHGCGNGSGAVDPLREEVEALVAHWNLCINLGGFFVGLFSVTLFGPWSDSVGRRPVLVLPAVGMAVQAAVYLLVMYLRLHVAYLLLGRIISGLLGDYNLILAGCFASVADSSNQRTRTFRVAILEACLGVAGMVASVGGGQWRKAEGYINPFWLVLAASLAAALYAALCLQETVKQRRAAKLLTLQHYKAVYKLYTAPEDLSSRRKLALYSLAFFLLVTVHFGTKDLYVLYELGSPLCWASDLIGYGSAASYLAYLSSLGGLRLLQLCLEDTWVAEIGLISNIAGLVVISLATTTPLMFTGYGIMFLSMAATPVIRAKLSKLVGETEQGALFASVACVEGLCSLVATGVFNSLYPSTLHFMRGFPFLFGAILLLIPAAIMGWIEIQDSNLQYSHFSDASSSPADG
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Heme signaling | Gallus gallus |
| Iron uptake and transport | Gallus gallus |
| Metabolism of folate and pterines | Gallus gallus |
