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Mannan-binding lectin serine protease 2

Summary

UniProt ID

O00187

Gene Symbol

MASP2

Organism

Homo sapiens (human)

External Links

GlyGen: O00187
PubChem: O00187
The Human Metabolome Database: HMDBP07788

Annotation

Keyword

3D-structure
Alternative splicing
Autocatalytic cleavage
Calcium
Complement pathway
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Hydroxylation
Metal-binding
Reference proteome
Repeat
Secreted
Serine protease
Signal
Sushi

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
proteolysis
complement activation, classical pathway
complement activation, lectin pathway

Displaying **all 3** entries
GO Term
extracellular exosome
extracellular region
extracellular space

Displaying **all 6** entries
GO Term
peptidase activity
identical protein binding
calcium-dependent protein binding
serine-type endopeptidase activity
calcium ion binding
complement component C4b binding

Annotation information from UniProt.

Sequence

MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites