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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Toll-like receptor 4
Summary
- UniProt ID
- O00206
- Gene Symbol
-
- TLR4
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O00206
- PubChem
- O00206
- The Human Metabolome Database
- HMDBP02639
- The O-GlcNAc Database
- O00206
Annotation
- Keyword
-
- 3D-structure
- Age-related macular degeneration
- Alternative splicing
- Cell membrane
- Cell projection
- Direct protein sequencing
- Disulfide bond
- Endosome
- Glycoprotein
- Inflammatory response
- Innate immunity
- Leucine-rich repeat
- NAD
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| plasma membrane |
| receptor complex |
| lipopolysaccharide receptor complex |
| ruffle |
| phagocytic cup |
| endosome membrane |
| early endosome |
| external side of plasma membrane |
| cell surface |
Sequence
MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 35 | N-linked (GlcNAc...) asparagine |
|
||
| 173 | N-linked (GlcNAc...) asparagine |
|
||
| 205 | N-linked (GlcNAc...) asparagine |
|
||
| 282 | N-linked (GlcNAc...) asparagine |
|
||
| 309 | N-linked (GlcNAc...) asparagine |
|
||
| 497 | N-linked (GlcNAc...) asparagine |
|
||
| 526 | N-linked (GlcNAc...) asparagine |
|
||
| 575 | N-linked (GlcNAc...) asparagine |
|
||
| 624 | N-linked (GlcNAc...) asparagine |
|
||
| 630 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | Homo sapiens |
| ER-Phagosome pathway | Homo sapiens |
| Heme signaling | Homo sapiens |
| IKK complex recruitment mediated by RIP1 | Homo sapiens |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | Homo sapiens |
| IRAK4 deficiency (TLR2/4) | Homo sapiens |
| Ligand-dependent caspase activation | Homo sapiens |
| MyD88 deficiency (TLR2/4) | Homo sapiens |
| MyD88-independent TLR4 cascade | Homo sapiens |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | Homo sapiens |
Human Protein Atlas