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MIRAGE
E3 SUMO-protein ligase CBX4
Summary
- UniProt ID
- O00257
- Gene Symbol
-
- CBX4
- Gene ID
- 8535
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Chromatin regulator
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Reference proteome
- Repressor
- Transcription regulation
- Transferase
- Ubl conjugation
- Ubl conjugation pathway
- Gene Ontology (GO)
| GO Term |
|---|
| nucleoplasm |
| PRC1 complex |
| nuclear speck |
| nucleus |
| nuclear body |
| PcG protein complex |
Sequence
MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAADERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 184 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Oxidative Stress Induced Senescence | Homo sapiens |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | Homo sapiens |
| Regulation of PTEN gene transcription | Homo sapiens |
| SUMOylation of DNA damage response and repair proteins | Homo sapiens |
| SUMOylation of DNA methylation proteins | Homo sapiens |
| SUMOylation of RNA binding proteins | Homo sapiens |
| SUMOylation of chromatin organization proteins | Homo sapiens |
| SUMOylation of transcription cofactors | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:684 | hepatocellular carcinoma |
