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cGMP-dependent 3',5'-cyclic phosphodiesterase

Summary

UniProt ID

O00408

Gene Symbol

PDE2A

Organism

Homo sapiens (human)

External Links

GlyGen: O00408
PubChem: O00408
The Human Metabolome Database: HMDBP00617
The O-GlcNAc Database: O00408

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytoplasm
Disease variant
Hydrolase
Intellectual disability
Metal-binding
Mitochondrion inner membrane
Mitochondrion outer membrane
Myristate
Palmitate
Reference proteome
Repeat
Zinc
cAMP
cGMP-binding

Gene Ontology (GO)

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GO Term
cellular response to granulocyte macrophage colony-stimulating factor stimulus
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
cellular response to 2,3,7,8-tetrachlorodibenzodioxine
cGMP catabolic process
negative regulation of transcription by RNA polymerase II
regulation of mitochondrion organization
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
regulation of cGMP-mediated signaling
negative regulation of cGMP-mediated signaling
cAMP-mediated signaling

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GO Term
nucleus
cytoplasm
Golgi apparatus
plasma membrane
synaptic membrane
mitochondrial inner membrane
mitochondrial matrix
cytosol
endoplasmic reticulum
mitochondrial outer membrane

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GO Term
TPR domain binding
identical protein binding
protein homodimerization activity
magnesium ion binding
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cAMP binding
cGMP binding
3',5'-cyclic-GMP phosphodiesterase activity
zinc ion binding

Annotation information from UniProt.

Sequence

MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites