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Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Summary

UniProt ID

O00443

Gene Symbol

PIK3C2A

Organism

Homo sapiens (human)

External Links

GlyGen

O00443

PubChem

O00443

SwissLipids

SLP:000000892

The Human Metabolome Database

HMDBP03120

The O-GlcNAc Database

O00443

O-GlcNAcAtlas

O00443

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cataract
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Disease variant
Dwarfism
Endocytosis
Exocytosis
Golgi apparatus
Kinase
Lipid metabolism
Nucleus
Phosphoprotein
Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 10** of 15 in total

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GO Term
phosphorylation
cell migration
membrane organization
positive regulation of autophagy
phosphatidylinositol-3-phosphate biosynthetic process
clathrin coat assembly
phosphatidylinositol biosynthetic process
epidermal growth factor receptor signaling pathway
vascular associated smooth muscle contraction
platelet-derived growth factor receptor signaling pathway

Displaying entries **1 - 10** of 11 in total

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GO Term
cytoplasm
plasma membrane
membrane
intracellular membrane-bounded organelle
vesicle
extracellular exosome
clathrin-coated vesicle
cytosol
nucleoplasm
trans-Golgi network

Displaying **all 6** entries
GO Term
ATP binding
phosphatidylinositol binding
1-phosphatidylinositol-4-phosphate 3-kinase activity
clathrin binding
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
1-phosphatidylinositol-3-kinase activity

Annotation information from UniProt.

Sequence

MAQISSNSGFKECPSSHPEPTRAKDVDKEEALQMEAEALAKLQKDRQVTDNQRGFELSSSTRKKAQVYNKQDYDLMVFPESDSQKRALDIDVEKLTQAELEKLLLDDSFETKKTPVLPVTPILSPSFSAQLYFRPTIQRGQWPPGLPGPSTYALPSIYPSTYSKQAAFQNGFNPRMPTFPSTEPIYLSLPGQSPYFSYPLTPATPFHPQGSLPIYRPVVSTDMAKLFDKIASTSEFLKNGKARTDLEITDSKVSNLQVSPKSEDISKFDWLDLDPLSKPKVDNVEVLDHEEEKNVSSLLAKDPWDAVLLEERSTANCHLERKVNGKSLSVATVTRSQSLNIRTTQLAKAQGHISQKDPNGTSSLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGENASVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKPCKEAMTRHPVEELLDSYHNQVELALQIENQHRAVDQVIKAVRKICSALDGVETLAITESVKKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLRLHANSGRSPTDCAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPDSNKQRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGYVMERIVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSMERVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSADAGSFSPTPGQIGGAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKETVKWYQLTAATYL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	GlyTouCan ID	Source
334	G49108TO	GlyGen The O-GlcNAc Database
1327	G49108TO	GlyGen The O-GlcNAc Database
1335	G49108TO	GlyGen The O-GlcNAc Database
1415	G49108TO	GlyGen
1417	G49108TO	GlyGen
1648	G49108TO	GlyGen The O-GlcNAc Database
1651	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Clathrin-mediated endocytosis	Homo sapiens
Golgi Associated Vesicle Biogenesis	Homo sapiens
Synthesis of PIPs at the Golgi membrane	Homo sapiens
Synthesis of PIPs at the early endosome membrane	Homo sapiens
Synthesis of PIPs at the late endosome membrane	Homo sapiens
Synthesis of PIPs at the plasma membrane	Homo sapiens

Human Protein Atlas

ENSG00000011405

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **31 - 40** of **106** in total

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DO ID	Disease Name	Source
DOID:0110289	autosomal recessive limb-girdle muscular dystrophy type 2Y	DisGeNET DisGeNET
DOID:0110292	autosomal recessive limb-girdle muscular dystrophy type 2O	DisGeNET DisGeNET
DOID:0110293	autosomal recessive limb-girdle muscular dystrophy type 2P	DisGeNET DisGeNET
DOID:0110294	autosomal recessive limb-girdle muscular dystrophy type 2T	DisGeNET DisGeNET
DOID:0110295	autosomal recessive limb-girdle muscular dystrophy type 2U	DisGeNET DisGeNET
DOID:0110296	autosomal recessive limb-girdle muscular dystrophy type 2M	DisGeNET DisGeNET
DOID:0110297	autosomal recessive limb-girdle muscular dystrophy type 2K	DisGeNET DisGeNET
DOID:0110298	autosomal recessive limb-girdle muscular dystrophy type 2N	DisGeNET DisGeNET
DOID:0110299	autosomal recessive limb-girdle muscular dystrophy type 2I	DisGeNET DisGeNET
DOID:0110300	obsolete autosomal dominant limb-girdle muscular dystrophy type 1A	DisGeNET DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements