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Aurora kinase A

Summary

UniProt ID

O14965

Gene Symbol

AURKA
AIK
AIRK1
ARK1
AURA
AYK1
BTAK
IAK1
STK15
STK6

Organism

Homo sapiens (human)

External Links

GlyGen: O14965
PubChem: O14965
The Human Metabolome Database: HMDBP01317
The O-GlcNAc Database: O14965

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Cilium
Cilium biogenesis/degradation
Cytoskeleton
Isopeptide bond
Microtubule
Mitosis
Phosphoprotein
Proto-oncogene
Reference proteome
Serine/threonine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 32 in total

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GO Term
regulation of protein stability
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autophosphorylation
regulation of signal transduction by p53 class mediator
G2/M transition of mitotic cell cycle
spindle organization
mitotic spindle organization
spindle assembly involved in female meiosis I
mitotic cell cycle
protein phosphorylation

Displaying entries **1 - 10** of 24 in total

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GO Term
axon hillock
centriole
cytosol
kinetochore
nucleoplasm
centrosome
spindle
spindle microtubule
postsynaptic density
nucleus

Displaying **all 10** entries
GO Term
ubiquitin protein ligase binding
protein heterodimerization activity
molecular function activator activity
protein serine/threonine/tyrosine kinase activity
ATP binding
histone H3S10 kinase activity
protein serine kinase activity
protein kinase activity
protein serine/threonine kinase activity
protein kinase binding

Annotation information from UniProt.

Sequence

MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	Homo sapiens
AURKA Activation by TPX2	Homo sapiens
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	Homo sapiens
Interaction between PHLDA1 and AURKA	Homo sapiens
Regulation of PLK1 Activity at G2/M Transition	Homo sapiens
Regulation of TP53 Activity through Phosphorylation	Homo sapiens
SUMOylation of DNA replication proteins	Homo sapiens
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	Homo sapiens