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A disintegrin and metalloproteinase with thrombospondin motifs 3

Summary

UniProt ID

O15072

Gene Symbol

ADAMTS3
KIAA0366

Gene ID

9508

Organism

Homo sapiens (human)

External Links

GlyGen: O15072
Re-Glyco: O15072

Annotation

Keyword

Cleavage on pair of basic residues
Disease variant
Disulfide bond
Extracellular matrix
Glycoprotein
Heparin-binding
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
extracellular region
extracellular space
extracellular matrix
extracellular exosome

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 9** entries
GO Term
supramolecular fiber organization
collagen fibril organization
collagen catabolic process
vascular endothelial growth factor production
collagen biosynthetic process
positive regulation of vascular endothelial growth factor signaling pathway
in utero embryonic development
protein processing
extracellular matrix organization

Displaying **all 4** entries
GO Term
heparin binding
zinc ion binding
endopeptidase activity
metalloendopeptidase activity

Annotation information from UniProt.

Sequence

MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRSSTLER

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 17 in total

1

2

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Position	Description	GlyTouCan ID	Source
83	N-linked (GlcNAc...) asparagine		UniProt GlyGen
119	N-linked (GlcNAc...) asparagine		UniProt GlyGen
242	N-linked (GlcNAc...) asparagine		UniProt GlyGen
345	N-linked (GlcNAc...) asparagine	G83460ZZ	UniProt GlyGen
475	N-linked (GlcNAc...) asparagine		UniProt GlyGen
814	N-linked (GlcNAc...) asparagine		UniProt GlyGen
942	N-linked (GlcNAc...) asparagine	G62765YT	UniProt GlyGen
1082		G57321FI	GlyGen
1087		G57321FI	GlyGen
1088		G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Collagen biosynthesis and modifying enzymes	Homo sapiens
Defective B3GALTL causes PpS	Homo sapiens
O-glycosylation of TSR domain-containing proteins	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060366	Hennekam syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements