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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
A disintegrin and metalloproteinase with thrombospondin motifs 3
Summary
- UniProt ID
- O15072
- Gene Symbol
-
- ADAMTS3
- KIAA0366
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Cleavage on pair of basic residues
- Disease variant
- Disulfide bond
- Extracellular matrix
- Glycoprotein
- Heparin-binding
- Metal-binding
- Metalloprotease
- Reference proteome
- Repeat
- Signal
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| extracellular matrix |
| extracellular exosome |
| GO Term |
|---|
| heparin binding |
| zinc ion binding |
| endopeptidase activity |
| metalloendopeptidase activity |
Sequence
MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRSSTLER
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 83 | N-linked (GlcNAc...) asparagine |
|
||
| 119 | N-linked (GlcNAc...) asparagine | |||
| 242 | N-linked (GlcNAc...) asparagine |
|
||
| 345 | N-linked (GlcNAc...) asparagine | |||
| 475 | N-linked (GlcNAc...) asparagine |
|
||
| 814 | N-linked (GlcNAc...) asparagine |
|
||
| 942 | N-linked (GlcNAc...) asparagine | |||
| 1082 |
|
|||
| 1087 |
|
|||
| 1088 |
|
G53434XO
G83460ZZ
G62765YT
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Collagen biosynthesis and modifying enzymes | Homo sapiens |
| Defective B3GALTL causes PpS | Homo sapiens |
| O-glycosylation of TSR domain-containing proteins | Homo sapiens |
