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UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Summary
- UniProt ID
- O15294
- Gene Symbol
-
- OGT
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O15294
- PubChem
- O15294
- The Human Metabolome Database
- HMDBP01707
- The O-GlcNAc Database
- O15294
- O-GlcNAcAtlas
- O15294
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Apoptosis
- Biological rhythms
- Cell membrane
- Cell projection
- Chromatin regulator
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Glycoprotein
- Glycosyltransferase
- Host-virus interaction
- Intellectual disability
- Lipid-binding
- Mitochondrion
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- TPR repeat
- Ubl conjugation
- Ubl conjugation pathway
- Gene Ontology (GO)
| GO Term |
|---|
| nucleoplasm |
| cell projection |
| glutamatergic synapse |
| protein N-acetylglucosaminyltransferase complex |
| NSL complex |
| cytosol |
| mitochondrial membrane |
| histone acetyltransferase complex |
| nucleus |
| plasma membrane |
Sequence
MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIKPVEVTESA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 3 | O-linked (GlcNAc) serine; alternate | |||
| 4 | O-linked (GlcNAc) serine; alternate | |||
| 10 | O-linked (GlcNAc) serine |
|
||
| 12 | O-linked (GlcNAc) threonine | |||
| 18 | O-linked (GlcNAc) serine |
|
||
| 38 | O-linked (GlcNAc) threonine |
|
||
| 52 | O-linked (GlcNAc) serine |
|
||
| 56 | O-linked (GlcNAc) serine |
|
||
| 391 |
|
|||
| 393 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Formation of WDR5-containing histone-modifying complexes | Homo sapiens |
| HATs acetylate histones | Homo sapiens |
| RIPK1-mediated regulated necrosis | Homo sapiens |
| Regulation of necroptotic cell death | Homo sapiens |
| UCH proteinases | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0050745 | diffuse large B-cell lymphoma | |
| DOID:0050782 | Zollinger-Ellison syndrome | |
| DOID:0050819 | obsolete Matthew-Wood syndrome | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080240 | non-syndromic X-linked intellectual disability 106 | |
| DOID:0080334 | aortic valve disease 2 | |
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0110035 | Alzheimer's disease 2 | |
| DOID:0110037 | Alzheimer's disease 5 |
