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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Summary
- UniProt ID
- O15357
- Gene Symbol
-
- INPPL1
- SHIP2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O15357
- PubChem
- O15357
- SwissLipids
- The Human Metabolome Database
- HMDBP03264
- The O-GlcNAc Database
- O15357
- O-GlcNAcAtlas
- O15357
Annotation
- Keyword
-
- 3D-structure
- Actin-binding
- Alternative splicing
- Cell adhesion
- Cell membrane
- Cell projection
- Cytoskeleton
- Diabetes mellitus
- Disease variant
- Hydrolase
- Immunity
- Lipid metabolism
- Nucleus
- Phosphoprotein
- Reference proteome
- SH2 domain
- SH3-binding
- Gene Ontology (GO)
| GO Term |
|---|
| endochondral ossification |
| immune system process |
| glucose metabolic process |
| endocytosis |
| apoptotic process |
| actin filament organization |
| cell adhesion |
| negative regulation of cell population proliferation |
| post-embryonic development |
| gene expression |
| GO Term |
|---|
| nucleus |
| Golgi apparatus |
| nuclear speck |
| lamellipodium |
| filopodium |
| cytosol |
| spindle pole |
| basal plasma membrane |
Sequence
MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGEREPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLSTVSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPSTRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAGMSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 276 |
|
G49108TO
G70994MS
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Interleukin receptor SHC signaling | Homo sapiens |
| Signaling by CSF1 (M-CSF) in myeloid cells | Homo sapiens |
| Synthesis of IP3 and IP4 in the cytosol | Homo sapiens |
| Synthesis of PIPs at the plasma membrane | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0050635 | alternating hemiplegia of childhood | |
| DOID:0050775 | schneckenbecken dysplasia | |
| DOID:0060224 | atrial fibrillation | |
| DOID:0060249 | scoliosis | |
| DOID:0060849 | osteoporosis-pseudoglioma syndrome | |
| DOID:0060870 | isolated growth hormone deficiency | |
| DOID:0080001 | bone disease | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080348 | Alzheimer's disease 1 |
