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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Toll-like receptor 3
Summary
- UniProt ID
- O15455
- Gene Symbol
-
- TLR3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Inflammatory response
- Innate immunity
- Isopeptide bond
- Leucine-rich repeat
- Phosphoprotein
- RNA-binding
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| extracellular space |
| cytoplasm |
| lysosomal membrane |
| plasma membrane |
| membrane |
| extracellular matrix |
| endoplasmic reticulum membrane |
| endosome membrane |
| early endosome |
Sequence
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKNSVH
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 52 | N-linked (GlcNAc...) asparagine | |||
| 57 | N-linked (GlcNAc...) asparagine | |||
| 70 | N-linked (GlcNAc...) asparagine | |||
| 124 | N-linked (GlcNAc...) asparagine | |||
| 140 |
|
|
||
| 196 | N-linked (GlcNAc...) asparagine | |||
| 247 | N-linked (GlcNAc...) asparagine | |||
| 252 | N-linked (GlcNAc...) asparagine | |||
| 265 | N-linked (GlcNAc...) asparagine | |||
| 275 | N-linked (GlcNAc...) asparagine |
|
G26377UA
G11101UV
G63136LV
G05962QB
G69521XL
G62765YT
G28541PG
G31852PQ
G02815KT
G57489SP
G80920RR
G00912UN
G59626AS
G70232NH
G27947YN
G43669FQ
G45395BF
G83460ZZ
G41071NU
G47644PP
G95865ZB
G23719VF
G11314AS
G92275SC
G27058EU
G37399XV
G37818NZ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| RIP-mediated NFkB activation via ZBP1 | Homo sapiens |
| RSV-host interactions | Homo sapiens |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | Homo sapiens |
| TICAM1 deficiency - HSE | Homo sapiens |
| TICAM1, RIP1-mediated IKK complex recruitment | Homo sapiens |
| TICAM1,TRAF6-dependent induction of TAK1 complex | Homo sapiens |
| TICAM1-dependent activation of IRF3/IRF7 | Homo sapiens |
| TLR3 deficiency - HSE | Homo sapiens |
| TLR3-mediated TICAM1-dependent programmed cell death | Homo sapiens |
| TRAF3 deficiency - HSE | Homo sapiens |
Human Protein Atlas