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MIRAGE
Pro-neuregulin-2, membrane-bound isoform

Summary
UniProt ID
O35569
Gene Symbol
  • Nrg2
  • Ntak
Gene ID
432361
Organism
Rattus norvegicus (Norway rat)
Re-Glyco
O35569
Annotation
Keyword
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • EGF-like domain
  • Glycoprotein
  • Growth factor
  • Immunoglobulin domain
  • Reference proteome
  • Secreted
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 4 entries
GO Term
glutamatergic synapse
GABA-ergic synapse
extracellular space
plasma membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MRQVCCSALPPPLEKARCSSYSYSDSSSSSSSNNSSSSTSSRSSSRSSSRSSRGSTTTTSSSENSGSNSGSIFRPAAPPEPRPQPQPQPRSPAARRAAARSRAAAAGGMRRDPAPGSSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCAPLERNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGEVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLHVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRRQMHHHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRREAETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYSQEERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGADMQRSYDSYYYPAAGPGPRRGACALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRTRGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGCGSASASDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPTRAKQDSGPL
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 5 entries
Position Description PubMed ID GlyTouCan ID Source
33 N-linked (GlcNAc...) asparagine
34 N-linked (GlcNAc...) asparagine
163 N-linked (GlcNAc...) asparagine
294 N-linked (GlcNAc...) asparagine
362 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 15 in total
Pathway Name Organism
Downregulation of ERBB2 signaling Rattus norvegicus
Downregulation of ERBB2:ERBB3 signaling Rattus norvegicus
ERBB2 Activates PTK6 Signaling Rattus norvegicus
ERBB2 Regulates Cell Motility Rattus norvegicus
GRB2 events in ERBB2 signaling Rattus norvegicus
GRB7 events in ERBB2 signaling Rattus norvegicus
PI3K events in ERBB2 signaling Rattus norvegicus
PI3K events in ERBB4 signaling Rattus norvegicus
PI3K/AKT Signaling Rattus norvegicus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Rattus norvegicus
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025