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Alpha-actinin-4

Summary

UniProt ID

O43707

Gene Symbol

ACTN4

Organism

Homo sapiens (human)

External Links

GlyGen: O43707
PubChem: O43707
The O-GlcNAc Database: O43707
RaftProt: O43707
O-GlcNAcAtlas: O43707

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Calcium
Cell junction
Cytoskeleton
Disease variant
Metal-binding
Nucleus
Phosphoprotein
Protein transport
Reference proteome
Repeat

Gene Ontology (GO)

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GO Term
actin cytoskeleton organization
positive regulation of transcription by RNA polymerase II
muscle cell development
protein transport
positive regulation of cell migration
regulation of apoptotic process
positive regulation of sodium:proton antiporter activity
vesicle transport along actin filament
tumor necrosis factor-mediated signaling pathway
peroxisome proliferator activated receptor signaling pathway

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GO Term
Z disc
perinuclear region of cytoplasm
extracellular region
extracellular space
nucleus
cytoplasm
plasma membrane
actin cytoskeleton
cell junction
protein-containing complex

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GO Term
transcription coactivator activity
calcium ion binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding
nucleoside binding
RNA binding
actin binding
integrin binding
nuclear receptor binding
nuclear receptor coactivator activity
chromatin DNA binding

Annotation information from UniProt.

Sequence

MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites