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MIRAGE
Tolloid-like protein 1
Summary
- UniProt ID
- O43897
- Gene Symbol
-
- TLL
- TLL1
- Gene ID
- 7092
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Atrial septal defect
- Calcium
- Developmental protein
- Differentiation
- Disease variant
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Metal-binding
- Metalloprotease
- Reference proteome
- Repeat
- Secreted
- Signal
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| GO Term |
|---|
| skeletal system development |
| collagen fibril organization |
| protein processing |
| cell differentiation |
| dorsal/ventral pattern formation |
| GO Term |
|---|
| serine-type endopeptidase activity |
| calcium ion binding |
| zinc ion binding |
| metalloendopeptidase activity |
Sequence
MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 125 |
|
|||
| 169 | N-linked (GlcNAc...) asparagine | |||
| 359 | N-linked (GlcNAc...) asparagine |
|
||
| 382 |
|
|
||
| 390 | N-linked (GlcNAc...) asparagine | |||
| 626 | N-linked (GlcNAc...) asparagine | |||
| 807 |
|
|
G83460ZZ
G82830MN
G71940EH
G80920RR
G62765YT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Anchoring fibril formation | Homo sapiens |
| Collagen biosynthesis and modifying enzymes | Homo sapiens |
| Crosslinking of collagen fibrils | Homo sapiens |
| Degradation of the extracellular matrix | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110111 | atrial heart septal defect 6 | |
| DOID:1682 | congenital heart disease | |
| DOID:3393 | coronary artery disease |
