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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Summary
- UniProt ID
- O60825
- Gene Symbol
-
- PFKFB2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O60825
- PubChem
- O60825
- The Human Metabolome Database
- HMDBP00804
- The O-GlcNAc Database
- O60825
- O-GlcNAcAtlas
- O60825
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Hydrolase
- Kinase
- Multifunctional enzyme
- Phosphoprotein
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| cytosol |
| nucleoplasm |
| GO Term |
|---|
| ATP binding |
| protein kinase binding |
| 6-phosphofructo-2-kinase activity |
| fructose-2,6-bisphosphate 2-phosphatase activity |
Sequence
MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPRNYSVGSRPLKPLSPLRAQDMQEGAD
Glycosylation Sites
G80920RR
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080144 | childhood acute lymphocytic leukemia | |
| DOID:10534 | stomach cancer | |
| DOID:1612 | breast cancer | |
| DOID:162 | cancer | |
| DOID:1909 | melanoma | |
| DOID:3068 | glioblastoma | |
| DOID:3070 | high grade glioma | |
| DOID:3074 | giant cell glioblastoma | |
| DOID:3347 | osteosarcoma | |
| DOID:3376 | bone osteosarcoma |
